Asymmetric epoxidation of cis-alkenes mediated by iminium salts: Highly enantioselective synthesis of levcromakalim

P. C. B. Bulman Page, B. R. Buckley, H. Heaney, A. J. Blacker

Research output: Contribution to journalArticlepeer-review

84 Citations (Scopus)

Abstract

A range of cis-substituted olefins has been epoxidized with a new dihydroisoquinolinium salt catalyst, using tetraphenylphosphonium monoperoxysulfate as the stoichiometric oxidant, giving ee's of up to 97%. The reaction has been used as the key step in an enantioselertive synthesis of the antihypertensive agent levcromakalim.
Original languageEnglish
Pages (from-to)375-377
Number of pages3
JournalOrganic Letters
Volume7
Issue number3
DOIs
Publication statusPublished - 2005

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