Abstract
A range of cis-substituted olefins has been epoxidized with a new dihydroisoquinolinium salt catalyst, using tetraphenylphosphonium monoperoxysulfate as the stoichiometric oxidant, giving ee's of up to 97%. The reaction has been used as the key step in an enantioselertive synthesis of the antihypertensive agent levcromakalim.
Original language | English |
---|---|
Pages (from-to) | 375-377 |
Number of pages | 3 |
Journal | Organic Letters |
Volume | 7 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2005 |