Abstract
Image registration is a gateway technology for Developmental Systems Biology, enabling computational analysis of related datasets within a shared coordinate system. Many registration tools rely on landmarks to ensure that datasets are correctly aligned; yet suitable landmarks are not present in many datasets. Atlas Toolkit is a Fiji/ImageJ plugin collection offering elastic group-wise registration of 3D morphological datasets, guided by segmentation of the interesting morphology. We demonstrate the method by combinatorial mapping of cell signalling events in the developing eyes of chick embryos, and use the integrated datasets to predictively enumerate Gene Regulatory Network states.
Original language | English |
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Article number | 20732 |
Journal | Scientific Reports |
Volume | 6 |
Early online date | 11 Feb 2016 |
DOIs | |
Publication status | Published - 11 Feb 2016 |
Profiles
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Timothy Grocott
- School of Biological Sciences - Lecturer in Biomedicine
- Cells and Tissues - Member
Person: Research Group Member, Academic, Teaching & Research
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Andrea Münsterberg
- School of Biological Sciences - Professor of Developmental Biology
- Cells and Tissues - Member
Person: Research Group Member, Academic, Teaching & Research