Atlas Toolkit: Fast registration of 3D morphological datasets in the absence of landmarks

Timothy Grocott (Lead Author), Paul Thomas, Andrea Munsterberg

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5 Citations (Scopus)
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Abstract

Image registration is a gateway technology for Developmental Systems Biology, enabling computational analysis of related datasets within a shared coordinate system. Many registration tools rely on landmarks to ensure that datasets are correctly aligned; yet suitable landmarks are not present in many datasets. Atlas Toolkit is a Fiji/ImageJ plugin collection offering elastic group-wise registration of 3D morphological datasets, guided by segmentation of the interesting morphology. We demonstrate the method by combinatorial mapping of cell signalling events in the developing eyes of chick embryos, and use the integrated datasets to predictively enumerate Gene Regulatory Network states.
Original languageEnglish
Article number20732
JournalScientific Reports
Volume6
Early online date11 Feb 2016
DOIs
Publication statusPublished - 11 Feb 2016

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