Atoms to phenotypes: Molecular design principles of cellular energy metabolism

Abhishek Singharoy, Christopher Maffeo, Karelia H. Delgado-Magnero, David J. K. Swainsbury, Melih Sener, Ulrich Kleinekathöfer, John W. Vant, Jonathan Nguyen, Andrew Hitchcock, Barry Isralewitz, Ivan Teo, Danielle E. Chandler, John E. Stone, James C. Phillips, Taras V. Pogorelov, M. Ilaria Mallus, Christophe Chipot, Zaida Luthey-Schulten, D. Peter Tieleman, C. Neil HunterEmad Tajkhorshid, Aleksei Aksimentiev, Klaus Schulten

Research output: Contribution to journalArticlepeer-review

103 Citations (Scopus)


A full atomic resolution model of an entire organelle, the photosynthetic chromatophore vesicle of a purple bacterium, is constructed and reveals how the photosynthetic apparatus is optimized for ATP production in low-light habitats.

Original languageEnglish
Pages (from-to)1098-1111.e23
Number of pages14
Issue number5
Publication statusPublished - 14 Nov 2019


  • bioenergetics
  • biological membranes
  • charge transport
  • chromatophore
  • integrative model
  • MD
  • mitochondria
  • molecular dynamics simulation
  • optical spectroscopy
  • photosynthesis

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