Bacteriophage treatment significantly reduces viable Clostridium difficile and prevents toxin production in an in vitro model system

Emma Meader, Melinda J. Mayer, Michael J. Gasson, Dietmar Steverding, Simon R. Carding, Arjan Narbad

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)


Clostridium difficile is primarily a nosocomial pathogen, causing thousands of cases of antibiotic-associated diarrhoea in the UK each year. In this study, we used a batch fermentation model of a C. difficile colonised system to evaluate the potential of a prophylactic and a remedial bacteriophage treatment regime to control the pathogen. It is shown that the prophylaxis regime was effective at preventing the growth of C. difficile (p =
Original languageEnglish
Pages (from-to)549-554
Number of pages6
Issue number6
Publication statusPublished - 2010

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