Bacteriophage treatment significantly reduces viable Clostridium difficile and prevents toxin production in an in vitro model system

Emma Meader; Melinda J. Mayer; Michael J. Gasson; Dietmar Steverding; Simon R. Carding; Arjan Narbad

doi:10.1016/j.anaerobe.2010.08.006

Bacteriophage treatment significantly reduces viable Clostridium difficile and prevents toxin production in an in vitro model system

Emma Meader, Melinda J. Mayer, Michael J. Gasson, Dietmar Steverding, Simon R. Carding, Arjan Narbad

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

Clostridium difficile is primarily a nosocomial pathogen, causing thousands of cases of antibiotic-associated diarrhoea in the UK each year. In this study, we used a batch fermentation model of a C. difficile colonised system to evaluate the potential of a prophylactic and a remedial bacteriophage treatment regime to control the pathogen. It is shown that the prophylaxis regime was effective at preventing the growth of C. difficile (p =

Original language	English
Pages (from-to)	549-554
Number of pages	6
Journal	Anaerobe
Volume	16
Issue number	6
Early online date	3 Sep 2010
DOIs	https://doi.org/10.1016/j.anaerobe.2010.08.006
Publication status	Published - Dec 2010

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10.1016/j.anaerobe.2010.08.006

Cite this

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abstract = "Clostridium difficile is primarily a nosocomial pathogen, causing thousands of cases of antibiotic-associated diarrhoea in the UK each year. In this study, we used a batch fermentation model of a C. difficile colonised system to evaluate the potential of a prophylactic and a remedial bacteriophage treatment regime to control the pathogen. It is shown that the prophylaxis regime was effective at preventing the growth of C. difficile (p = ",

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AU - Carding, Simon R.

AU - Narbad, Arjan

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