Bacteriophage treatment significantly reduces viable Clostridium difficile and prevents toxin production in an in vitro model system.

Emma Meader, Melinda J Mayer, Michael J Gasson, Dietmar Steverding, Simon R Carding, Arjan Narbad

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


Clostridium difficile is primarily a nosocomial pathogen, causing thousands of cases of antibiotic-associated diarrhoea in the UK each year. In this study, we used a batch fermentation model of a C. difficile colonised system to evaluate the potential of a prophylactic and a remedial bacteriophage treatment regime to control the pathogen. It is shown that the prophylaxis regime was effective at preventing the growth of C. difficile (p =
Original languageEnglish
Pages (from-to)549-54
Number of pages6
Issue number6
Publication statusPublished - 2010

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