Bacteriophage treatment significantly reduces viable Clostridium difficile and prevents toxin production in an in vitro model system.

Emma Meader; Melinda J Mayer; Michael J Gasson; Dietmar Steverding; Simon R Carding; Arjan Narbad

Bacteriophage treatment significantly reduces viable Clostridium difficile and prevents toxin production in an in vitro model system.

Emma Meader, Melinda J Mayer, Michael J Gasson, Dietmar Steverding, Simon R Carding, Arjan Narbad

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Clostridium difficile is primarily a nosocomial pathogen, causing thousands of cases of antibiotic-associated diarrhoea in the UK each year. In this study, we used a batch fermentation model of a C. difficile colonised system to evaluate the potential of a prophylactic and a remedial bacteriophage treatment regime to control the pathogen. It is shown that the prophylaxis regime was effective at preventing the growth of C. difficile (p =

Original language	English
Pages (from-to)	549-54
Number of pages	6
Journal	Anaerobe
Volume	16
Issue number	6
Publication status	Published - 2010

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Cite this

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abstract = "Clostridium difficile is primarily a nosocomial pathogen, causing thousands of cases of antibiotic-associated diarrhoea in the UK each year. In this study, we used a batch fermentation model of a C. difficile colonised system to evaluate the potential of a prophylactic and a remedial bacteriophage treatment regime to control the pathogen. It is shown that the prophylaxis regime was effective at preventing the growth of C. difficile (p = ",

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AU - Meader, Emma

AU - Mayer, Melinda J

AU - Gasson, Michael J

AU - Steverding, Dietmar

AU - Carding, Simon R

AU - Narbad, Arjan

PY - 2010

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AB - Clostridium difficile is primarily a nosocomial pathogen, causing thousands of cases of antibiotic-associated diarrhoea in the UK each year. In this study, we used a batch fermentation model of a C. difficile colonised system to evaluate the potential of a prophylactic and a remedial bacteriophage treatment regime to control the pathogen. It is shown that the prophylaxis regime was effective at preventing the growth of C. difficile (p =

M3 - Article

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SP - 549

EP - 554

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JF - Anaerobe

SN - 1095-8274

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