Barrett's esophagus: progression to adenocarcinoma and markers

Dianchun Fang, Kiron M Das, Weibiao Cao, Usha Malhotra, George Triadafilopoulos, Robert M Najarian, Laura J Hardie, Charles J Lightdale, Ian L P Beales, Valter Nilton Felix, Paul M Schneider, Andrew M Bellizzi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The following on progression to adenocarcinoma and markers of Barrett's esophagus includes commentariess on the expression of claudin 4 in Barrett's adenocarcinoma; the role of acid and bile salts; the role of insulin-like growth factor; the value of reactive oxygen species; the importance of abnormal methylation; genetic alterations in stromal cells and genomic changes in the epithelial cells; the value of confocal laser endomicroscopy for the subsurface analysis of the mucosa; indications for statins as adjuvant chemotherapeutic agent; the sequence of molecular events in malignant progression in Barrett's mucosa; and the value of the macroscopic markers and of p53 mutations.
Original languageEnglish
Pages (from-to)210-29
Number of pages20
JournalAnnals of the New York Academy of Sciences
Volume1232
DOIs
Publication statusPublished - Sep 2011

Keywords

  • Adenocarcinoma
  • Barrett Esophagus
  • Disease Progression
  • Esophageal Neoplasms
  • Humans
  • NADPH Oxidase
  • Reverse Transcriptase Polymerase Chain Reaction
  • Tumor Markers, Biological

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