Abstract
The following on progression to adenocarcinoma and markers of Barrett's esophagus includes commentariess on the expression of claudin 4 in Barrett's adenocarcinoma; the role of acid and bile salts; the role of insulin-like growth factor; the value of reactive oxygen species; the importance of abnormal methylation; genetic alterations in stromal cells and genomic changes in the epithelial cells; the value of confocal laser endomicroscopy for the subsurface analysis of the mucosa; indications for statins as adjuvant chemotherapeutic agent; the sequence of molecular events in malignant progression in Barrett's mucosa; and the value of the macroscopic markers and of p53 mutations.
Original language | English |
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Pages (from-to) | 210-29 |
Number of pages | 20 |
Journal | Annals of the New York Academy of Sciences |
Volume | 1232 |
DOIs | |
Publication status | Published - Sept 2011 |
Keywords
- Adenocarcinoma
- Barrett Esophagus
- Disease Progression
- Esophageal Neoplasms
- Humans
- NADPH Oxidase
- Reverse Transcriptase Polymerase Chain Reaction
- Tumor Markers, Biological