@article{d66217ff390a40bebf699e62adeb619a,
title = "Batzella, Crambe and Monanchora: Highly prolific marine sponge genera yielding compounds with potential applications for cancer and other therapeutic areas",
abstract = "Pyrroloquinoline and guanidine-derived alkaloids present distinct groups of marine secondary metabolites with structural diversity that displayed potentialities in biological research. A considerable number of these molecular architectures had been recorded from marine sponges belonging to different marine genera, including Batzella, Crambe, Monanchora, Clathria, Ptilocaulis and New Caledonian starfishes Fromia monilis and Celerina heffernani. In this review, we aim to comprehensively cover the chemodiversity and the bioactivities landmarks centered around the chemical constituents exclusively isolated from these three marine genera including Batzella, Crambe and Monanchora over the period 1981-2017, paying a special attention to the polycyclic guanidinic compounds and their proposed biomimetic landmarks. It is concluded that these marine sponge genera represent a rich source of novel compounds with potential applications for cancer and other therapeutic areas.",
keywords = "Batzella, Bioactivities, Biomimetic synthesis, Crambe, Guanidine alkaloids, Marine sponges, Monanchora, Poecilosclerida, Pyrroloquinoline alkaloids",
author = "Amr El-Demerdash and Atanasov, {Atanas G.} and Anupam Bishayee and Mamdouh Abdel-Mogib and Hooper, {John N.A.} and Ali Al-Mourabit",
note = "Funding Information: exclusively dedicated to the chemistry, biology and insights on the most leading biomimetic exclusively dedicated to the chemistry, biology and insights on the most leading biomimetic syntheses syntheses of guanidine derived natural products isolated from marine sponges of three genera of guanidine derived natural products isolated from marine sponges of three genera Batzella, Batzella, Crambe and Monanchora. One hundred forty-seven marine natural products were recorded Crambe and Monanchora. One hundred forty-seven marine natural products were recorded with distinct with distinct structural diversities that afforded wide scope of bioactivities. For their structural diversities that afforded wide scope of bioactivities. For their chemodiversity, along with chemodiversity, along with their displayed biological potentialities, they still present promising and their displayed biological potentialities, they still present promising and attractive marine species that attractive marine species that are worth attracting the worldwide interest of natural products are worth attracting the worldwide interest of natural products chemists and pharmacologists. chemists and pharmacologists. Acknowledgments: This work was supported by the mission sector of the Ministry of High Education of the Arab Republic of Egypt (Egyptian Cultural Bureau in Paris, France); Amr El-Demerdash{\textquoteright}s was granted and completely funded. Many thanks to Ali Al-Mourabit and his research team at the ICSN-CNRS for hosting, supervising and supplying with research facilities. Funding Information: This work was supported by the mission sector of the Ministry of High Education of the Arab Republic of Egypt (Egyptian Cultural Bureau in Paris, France); Amr El-Demerdash{\textquoteright}s was granted and completely funded. Many thanks to Ali Al-Mourabit and his research team at the ICSN-CNRS for hosting, supervising and supplying with research facilities. Publisher Copyright: {\textcopyright} 2018 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2018",
month = jan,
doi = "10.3390/nu10010033",
language = "English",
volume = "10",
journal = "Nutrients",
issn = "2072-6643",
publisher = "MDPI AG",
number = "1",
}
