BCL10 is rarely mutated in human prostate carcinoma, small cell lung cancer, head and neck tumours, renal carcinoma and sarcomas

S. Gill, J. Broni, S. Jefferies, P. Osin, G. Kovacs, N. J. Maitland, R. Eeles, S. M. Edwards, M. J. S. Dyer, T. G. Willis, the M. P. T. Collaborators, the St George’s Hospital Collaborators , C. S. Cooper

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We have used single-strand conformation polymorphism (SSCP) analysis to screen for mutations in the BCL 10 gene in 81 primary prostate carcinomas, 20 squamous cell cancers of the head and neck, 15 small-cell lung cancer cell lines, 24 renal carcinoma cell lines and 13 sarcoma cell lines. We failed to find evidence of somatically acquired mutations of the BCL10 gene suggesting that BCL 10 does not play a major role in the development of these malignancies.

Original languageEnglish
Pages (from-to)1565-1568
Number of pages4
JournalBritish Journal of Cancer
Issue number10
Publication statusPublished - 25 Jun 1999


  • BCL 10
  • Head and neck squamous cell cancers
  • Lung cancer
  • Mutation
  • Prostate cancer
  • Renal carcinoma
  • Sarcomas

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