Biflavonoids with cytotoxic and antibacterial activity from Ochna macrocalyx

Sharon Tang, Paul Bremner, Andreas Kortenkamp, Christina Schlage, AIexander Gray, S Gibbons, Michael Heinrich

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Six biflavonoid and related compounds were isolated from the ethanolic extract of Ochna macrocalyx bark. One is a new compound, the isoflavanone dimer dehydroxyhexaspermone C (1). Previously isolated compounds obtained from the bark are biisoflavonoid hexaspermone C (2), tetrahydrofuran derivative ochnone (3), furobenzopyran derivative cordigol (4), and biflavonoids calodenin B (5) and dihydrocalodenin B (6). Although 3 has already been isolated, its spectral data are presented here for the first time. isolated compounds were tested for cytotoxic activity on MCF-7 breast cancer cells using the MTT reduction assay method. Compound 5 showed cytotoxic activity (7 +/- 0.5 muM) and 6 showed moderate cytotoxicity (35 +/- 7 muM). In antibacterial assays performed using three strains of multi-drug resistant (mdr) Staphylococcus aureus (RN4220, XU212 and SA-1199-B) compounds 5 and in particular 6 showed strong antibacterial activity (MICs 5:64, 8,16 mug/mL 6:8, 8, 8 mug/mL, respectively). The ethanolic extract of the bark also showed NF-kappaB inhibitory activity.

Original languageEnglish
Pages (from-to)247-253
Number of pages7
JournalPlanta Medica
Volume69
Issue number3
DOIs
Publication statusPublished - Mar 2003

Keywords

  • Ochnaceae
  • Ochna macrocalyx
  • biflavonoids
  • antibacterial
  • mdr
  • cytotoxicity
  • NF-kappa B
  • ethnopharmacology
  • NATURAL-PRODUCTS
  • KAPPA-B

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