Bifunctional alkylating agents derived from duocarmycin SA: Potent antitumor activity with altered sequence selectivity

D. L. Boger, M. Searcey, W. C. Tse, Q. Jin

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11 Citations (Scopus)

Abstract

The series of four dimers derived from head to tail coupling of the two enantiomers of the duocarmycin SA alkylation subunit are described. (C) 2000 Elsevier Science Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)495-498
Number of pages4
JournalBioorganic & Medicinal Chemistry Letters
Volume10
Issue number5
Publication statusPublished - 2000

Keywords

  • AMIDE
  • CC-1065
  • PYRINDAMYCIN-A
  • STREPTOMYCES SP
  • BINDING
  • CATALYSIS
  • ANALOGS
  • DNA
  • SUBUNITS
  • ANTIBIOTICS

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