Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate

Maxi Meissner, Hilde Herrema, Theo H van Dijk, Albert Gerding, Rick Havinga, Theo Boer, Michael Müller, Dirk-Jan Reijngoud, Albert K Groen, Folkert Kuipers

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Bile acid sequestrants (BAS) reduce plasma glucose levels in type II diabetics and in murine models of diabetes but the mechanism herein is unknown. We hypothesized that sequestrant-induced changes in hepatic glucose metabolism would underlie reduced plasma glucose levels. Therefore, in vivo glucose metabolism was assessed in db/db mice on and off BAS using tracer methodology.
Original languageEnglish
Article numbere24564
JournalPLoS One
Volume6
Issue number11
DOIs
Publication statusPublished - 7 Nov 2011

Keywords

  • Animals
  • Bile Acids and Salts
  • Blood Glucose
  • Carbon Isotopes
  • Carnitine
  • Diabetes Mellitus, Experimental
  • Glucose
  • Liver
  • Metabolic Clearance Rate
  • Mice
  • Mice, Knockout
  • Muscle, Skeletal

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