Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate

Maxi Meissner, Hilde Herrema, Theo H. van Dijk, Albert Gerding, Rick Havinga, Theo Boer, Michael Müller, Dirk-Jan Reijngoud, Albert K. Groen, Folkert Kuipers

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16 Citations (Scopus)


Bile acid sequestrants (BAS) reduce plasma glucose levels in type II diabetics and in murine models of diabetes but the mechanism herein is unknown. We hypothesized that sequestrant-induced changes in hepatic glucose metabolism would underlie reduced plasma glucose levels. Therefore, in vivo glucose metabolism was assessed in db/db mice on and off BAS using tracer methodology.
Original languageEnglish
Article numbere24564
JournalPLoS One
Issue number11
Publication statusPublished - 7 Nov 2011


  • Animals
  • Bile Acids and Salts
  • Blood Glucose
  • Carbon Isotopes
  • Carnitine
  • Diabetes Mellitus, Experimental
  • Glucose
  • Liver
  • Metabolic Clearance Rate
  • Mice
  • Mice, Knockout
  • Muscle, Skeletal

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