Abstract
Bile acid sequestrants (BAS) reduce plasma glucose levels in type II diabetics and in murine models of diabetes but the mechanism herein is unknown. We hypothesized that sequestrant-induced changes in hepatic glucose metabolism would underlie reduced plasma glucose levels. Therefore, in vivo glucose metabolism was assessed in db/db mice on and off BAS using tracer methodology.
Original language | English |
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Article number | e24564 |
Journal | PLoS One |
Volume | 6 |
Issue number | 11 |
DOIs | |
Publication status | Published - 7 Nov 2011 |
Keywords
- Animals
- Bile Acids and Salts
- Blood Glucose
- Carbon Isotopes
- Carnitine
- Diabetes Mellitus, Experimental
- Glucose
- Liver
- Metabolic Clearance Rate
- Mice
- Mice, Knockout
- Muscle, Skeletal