Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate

Maxi Meissner; Hilde Herrema; Theo H. van Dijk; Albert Gerding; Rick Havinga; Theo Boer; Michael Müller; Dirk-Jan Reijngoud; Albert K. Groen; Folkert Kuipers

doi:10.1371/journal.pone.0024564

Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate

Maxi Meissner
, Hilde Herrema
, Theo H. van Dijk
, Albert Gerding
, Rick Havinga
, Theo Boer
, Michael Müller
, Dirk-Jan Reijngoud
, Albert K. Groen
, Folkert Kuipers

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Bile acid sequestrants (BAS) reduce plasma glucose levels in type II diabetics and in murine models of diabetes but the mechanism herein is unknown. We hypothesized that sequestrant-induced changes in hepatic glucose metabolism would underlie reduced plasma glucose levels. Therefore, in vivo glucose metabolism was assessed in db/db mice on and off BAS using tracer methodology.

Original language	English
Article number	e24564
Journal	PLoS One
Volume	6
Issue number	11
DOIs	https://doi.org/10.1371/journal.pone.0024564
Publication status	Published - 7 Nov 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Animals
Bile Acids and Salts
Blood Glucose
Carbon Isotopes
Carnitine
Diabetes Mellitus, Experimental
Glucose
Liver
Metabolic Clearance Rate
Mice
Mice, Knockout
Muscle, Skeletal

Access to Document

10.1371/journal.pone.0024564Licence: CC BY

Cite this

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abstract = "Bile acid sequestrants (BAS) reduce plasma glucose levels in type II diabetics and in murine models of diabetes but the mechanism herein is unknown. We hypothesized that sequestrant-induced changes in hepatic glucose metabolism would underlie reduced plasma glucose levels. Therefore, in vivo glucose metabolism was assessed in db/db mice on and off BAS using tracer methodology.",

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AU - Meissner, Maxi

AU - Herrema, Hilde

AU - van Dijk, Theo H.

AU - Gerding, Albert

AU - Havinga, Rick

AU - Boer, Theo

AU - Müller, Michael

AU - Reijngoud, Dirk-Jan

AU - Groen, Albert K.

AU - Kuipers, Folkert

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KW - Animals

KW - Bile Acids and Salts

KW - Blood Glucose

KW - Carbon Isotopes

KW - Carnitine

KW - Diabetes Mellitus, Experimental

KW - Glucose

KW - Liver

KW - Metabolic Clearance Rate

KW - Mice

KW - Mice, Knockout

KW - Muscle, Skeletal

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