TY - JOUR
T1 - Bioactive acetophenones from Plectranthus venteri
AU - Maree, Johanna E.
AU - Khondkar, Proma
AU - Kwapong, Awo A.
AU - Oyedemi, Blessing M.
AU - Aljarba, Tariq M.
AU - Stapleton, Paul
AU - Viljoen, Alvaro M.
AU - Gibbons, Simon
PY - 2014/12
Y1 - 2014/12
N2 - In a project to investigate the chemistry of South African Plectranthus species, from the dichloromethane extract of the aerial parts of Plectranthus venteri, we isolated two known natural product acetophenones, namely 2-hydroxy-3,4,5,6-tetramethoxy-acetophenone (1) and 2-hydroxy-4,5,6-trimethoxy-acetophenone (2). Structures were assigned using NMR spectroscopy and HRTOFESIMS. Compound 1 was previously synthesised as a precursor to the polymethoxylated flavone nobiletin. The acetophenones exhibited remarkable inhibitory activities against the transfer of the IncW plasmid R7K in a bacterial plasmid transfer inhibition assay.
AB - In a project to investigate the chemistry of South African Plectranthus species, from the dichloromethane extract of the aerial parts of Plectranthus venteri, we isolated two known natural product acetophenones, namely 2-hydroxy-3,4,5,6-tetramethoxy-acetophenone (1) and 2-hydroxy-4,5,6-trimethoxy-acetophenone (2). Structures were assigned using NMR spectroscopy and HRTOFESIMS. Compound 1 was previously synthesised as a precursor to the polymethoxylated flavone nobiletin. The acetophenones exhibited remarkable inhibitory activities against the transfer of the IncW plasmid R7K in a bacterial plasmid transfer inhibition assay.
KW - Acetophenones
KW - Bacterial plasmid transfer inhibition
KW - Lamiaceae
KW - Plectranthus venteri
UR - http://www.scopus.com/inward/record.url?scp=84914703007&partnerID=8YFLogxK
U2 - 10.1016/j.phytol.2014.10.021
DO - 10.1016/j.phytol.2014.10.021
M3 - Article
AN - SCOPUS:84914703007
VL - 10
SP - cxli-cxliv
JO - Phytochemistry Letters
JF - Phytochemistry Letters
SN - 1874-3900
ER -