Bioactive acetophenones from Plectranthus venteri

Johanna E. Maree, Proma Khondkar, Awo A. Kwapong, Blessing M. Oyedemi, Tariq M. Aljarba, Paul Stapleton, Alvaro M. Viljoen, Simon Gibbons

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Abstract

In a project to investigate the chemistry of South African Plectranthus species, from the dichloromethane extract of the aerial parts of Plectranthus venteri, we isolated two known natural product acetophenones, namely 2-hydroxy-3,4,5,6-tetramethoxy-acetophenone (1) and 2-hydroxy-4,5,6-trimethoxy-acetophenone (2). Structures were assigned using NMR spectroscopy and HRTOFESIMS. Compound 1 was previously synthesised as a precursor to the polymethoxylated flavone nobiletin. The acetophenones exhibited remarkable inhibitory activities against the transfer of the IncW plasmid R7K in a bacterial plasmid transfer inhibition assay.

Original languageEnglish
Pages (from-to)cxli-cxliv
Number of pages4
JournalPhytochemistry Letters
Volume10
Early online date31 Oct 2014
DOIs
Publication statusPublished - Dec 2014

Keywords

  • Acetophenones
  • Bacterial plasmid transfer inhibition
  • Lamiaceae
  • Plectranthus venteri

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