Biocatalytic production of tetrahydroisoquinolines

Bettina M. Ruff, S. Bräse, Sarah E. O'Connor

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

The promiscuity of the enzyme norcoclaurine synthase is described. This biocatalyst yielded a diverse array of substituted tetrahydroisoquinolines by cyclizing dopamine with various acetaldehydes in a Pictet–Spengler reaction. This enzymatic reaction may provide a biocatalytic route to a range of tetrahydroisoquinoline alkaloids.
Original languageEnglish
Pages (from-to)1071-1074
Number of pages4
JournalTetrahedron Letters
Volume53
Issue number9
DOIs
Publication statusPublished - 2012

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