Biocatalytic production of tetrahydroisoquinolines

Bettina M. Ruff; S. Bräse; Sarah E. O'Connor

doi:10.1016/j.tetlet.2011.12.089

Biocatalytic production of tetrahydroisoquinolines

Bettina M. Ruff, S. Bräse, Sarah E. O'Connor

School of Chemistry

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

The promiscuity of the enzyme norcoclaurine synthase is described. This biocatalyst yielded a diverse array of substituted tetrahydroisoquinolines by cyclizing dopamine with various acetaldehydes in a Pictet–Spengler reaction. This enzymatic reaction may provide a biocatalytic route to a range of tetrahydroisoquinoline alkaloids.

Original language	English
Pages (from-to)	1071-1074
Number of pages	4
Journal	Tetrahedron Letters
Volume	53
Issue number	9
DOIs	https://doi.org/10.1016/j.tetlet.2011.12.089
Publication status	Published - 2012

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10.1016/j.tetlet.2011.12.089

Cite this

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title = "Biocatalytic production of tetrahydroisoquinolines",

abstract = "The promiscuity of the enzyme norcoclaurine synthase is described. This biocatalyst yielded a diverse array of substituted tetrahydroisoquinolines by cyclizing dopamine with various acetaldehydes in a Pictet–Spengler reaction. This enzymatic reaction may provide a biocatalytic route to a range of tetrahydroisoquinoline alkaloids.",

author = "Ruff, {Bettina M.} and S. Br{\"a}se and O'Connor, {Sarah E.}",

year = "2012",

doi = "10.1016/j.tetlet.2011.12.089",

language = "English",

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journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier",

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T1 - Biocatalytic production of tetrahydroisoquinolines

AU - Ruff, Bettina M.

AU - Bräse, S.

AU - O'Connor, Sarah E.

PY - 2012

Y1 - 2012

N2 - The promiscuity of the enzyme norcoclaurine synthase is described. This biocatalyst yielded a diverse array of substituted tetrahydroisoquinolines by cyclizing dopamine with various acetaldehydes in a Pictet–Spengler reaction. This enzymatic reaction may provide a biocatalytic route to a range of tetrahydroisoquinoline alkaloids.

AB - The promiscuity of the enzyme norcoclaurine synthase is described. This biocatalyst yielded a diverse array of substituted tetrahydroisoquinolines by cyclizing dopamine with various acetaldehydes in a Pictet–Spengler reaction. This enzymatic reaction may provide a biocatalytic route to a range of tetrahydroisoquinoline alkaloids.

U2 - 10.1016/j.tetlet.2011.12.089

DO - 10.1016/j.tetlet.2011.12.089

M3 - Article

VL - 53

SP - 1071

EP - 1074

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 9

ER -