Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants

Katrin Geisler; Richard K. Hughes; Frank Sainsbury; George P. Lomonossoff; Martin Rejzek; Shirley Fairhurst; Carl-Erik Olsen; Mohammed Saddik Motawia; Rachel E. Melton; Andrew M. Hemmings; Søren Bak; Anne Osbourn

doi:10.1073/pnas.1309157110

Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants

Katrin Geisler
, Richard K. Hughes
, Frank Sainsbury
, George P. Lomonossoff
, Martin Rejzek
, Shirley Fairhurst
, Carl-Erik Olsen
, Mohammed Saddik Motawia
, Rachel E. Melton
, Andrew M. Hemmings
, Søren Bak
, Anne Osbourn

Research output: Contribution to journal › Article › peer-review

167 Citations (Scopus)

Original language	English
Pages (from-to)	E3360-E3367
Number of pages	8
Journal	Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Volume	110
Issue number	35
DOIs	https://doi.org/10.1073/pnas.1309157110
Publication status	Published - 27 Aug 2013

Keywords

CPMV-HT transient expression
cytochrome P450 monooxygenase CYP51 family
disease resistnace
neofunctionalization
terpenes

Access to Document

10.1073/pnas.1309157110

Cite this

Geisler, K., Hughes, R. K., Sainsbury, F., Lomonossoff, G. P., Rejzek, M., Fairhurst, S., Olsen, C.-E., Motawia, M. S., Melton, R. E., Hemmings, A. M., Bak, S., & Osbourn, A. (2013). Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 110(35), E3360-E3367. https://doi.org/10.1073/pnas.1309157110

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title = "Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants",

keywords = "CPMV-HT transient expression, cytochrome P450 monooxygenase CYP51 family, disease resistnace, neofunctionalization, terpenes",

author = "Katrin Geisler and Hughes, \{Richard K.\} and Frank Sainsbury and Lomonossoff, \{George P.\} and Martin Rejzek and Shirley Fairhurst and Carl-Erik Olsen and Motawia, \{Mohammed Saddik\} and Melton, \{Rachel E.\} and Hemmings, \{Andrew M.\} and S{\o}ren Bak and Anne Osbourn",

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day = "27",

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Geisler, K, Hughes, RK, Sainsbury, F, Lomonossoff, GP, Rejzek, M, Fairhurst, S, Olsen, C-E, Motawia, MS, Melton, RE, Hemmings, AM, Bak, S & Osbourn, A 2013, 'Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants', Proceedings of the National Academy of Sciences of the United States of America (PNAS), vol. 110, no. 35, pp. E3360-E3367. https://doi.org/10.1073/pnas.1309157110

Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants. / Geisler, Katrin; Hughes, Richard K.; Sainsbury, Frank et al.
In: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Vol. 110, No. 35, 27.08.2013, p. E3360-E3367.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants

AU - Geisler, Katrin

AU - Hughes, Richard K.

AU - Sainsbury, Frank

AU - Lomonossoff, George P.

AU - Rejzek, Martin

AU - Fairhurst, Shirley

AU - Olsen, Carl-Erik

AU - Motawia, Mohammed Saddik

AU - Melton, Rachel E.

AU - Hemmings, Andrew M.

AU - Bak, Søren

AU - Osbourn, Anne

PY - 2013/8/27

Y1 - 2013/8/27

KW - CPMV-HT transient expression

KW - cytochrome P450 monooxygenase CYP51 family

KW - disease resistnace

KW - neofunctionalization

KW - terpenes

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DO - 10.1073/pnas.1309157110

M3 - Article

SN - 0027-8424

VL - 110

SP - E3360-E3367

JO - Proceedings of the National Academy of Sciences of the United States of America (PNAS)

JF - Proceedings of the National Academy of Sciences of the United States of America (PNAS)

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