Biomarkers of Postsurgical Outcome in Dupuytren Disease

Orla Jupp, Michael Pullinger, Tom Marjoram, Martin Lott, Adrian J. Chojnowski, Ian M. Clark

Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution


We hypothesised that the measurement of circulating collagen-degrading matrix metalloproteinases (MMPs) would be predictive of postsurgical outcome after fasciectomy for Dupuytren disease (DD), measured through total extension deficit (TED). Assay of MMP-1, MMP-13 and MMP-14 in the plasma of DD patients showed poor correlation with change in TED after surgery. However, MMP-14 levels correlated with preoperative TED. In order to extend this study, we also measured the transcriptome in tissue samples from DD patients and showed that expression of specific genes correlated with preoperative and postoperative TED. These methodologies demonstrate the use of the approach in uncovering biomarkers which both illuminate the mechanism of the disease and have clinical utility.
Original languageEnglish
Title of host publicationDupuytren Disease and Related Diseases - The Cutting Edge
EditorsPaul M. N. Werker, Joseph Dias, Charles Eaton, Bert Reichert, Wolfgang Wach
Number of pages7
ISBN (Electronic)978-3-319-32199-8
ISBN (Print)978-3-319-32197-4
Publication statusPublished - 7 Sep 2016


  • Gene expression
  • qRT-PCR
  • Microarray
  • Biomarker
  • Recurrence

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