Bis(N-picolinamido)cobalt(II) Complexes Display Antifungal Activity toward Candida albicans and Aspergillus fumigatus

Laura H. D. Ghandhi, Stefan Bidula, Christopher M. Pask, Rianne M. Lord, Patrick C. McGowan

Research output: Contribution to journalArticlepeer-review

18 Downloads (Pure)

Abstract

This report highlights the synthesis and characterization of ten new bis(N-picolinamido)cobalt(II) complexes of the type [(L) 2CoX 2] 0/2+, whereby L=N-picolinamide ligand and X=diisothiocyanato (−NCS), dichlorido (−Cl) or diaqua (−OH 2) ligands. Single crystal X-ray (SC-XRD) analysis for nine of the structures are reported and confirm the picolinamide ligand is bound to the Co(II) center through a neutral N,O binding mode. With the addition of powder X-ray diffraction (PXRD), we have confirmed the cis and trans ligand arrangements of each complex. All complexes were screened against several fungal species and show increased antifungal activity. Notably, these complexes had significant activity against strains of Candida albicans and Aspergillus fumigatus, with several compounds exhibiting growth inhibition of >80 %, and onecompound inhibiting Aspergillus fumigatus hyphal growth by >90 %. Conversely, no antifungal activity was exhibited toward Cryptococcus neoformans and no cytotoxicity towards mammalian cell lines.

Original languageEnglish
Pages (from-to)3210-3221
Number of pages12
JournalChemMedChem
Volume16
Issue number20
Early online date29 Jul 2021
DOIs
Publication statusPublished - 15 Oct 2021

Keywords

  • Aspergillus fumigatus
  • Bioinorganic Chemistry
  • Candida albicans
  • Cobalt Complexes
  • Picolinamide ligands

Cite this