Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling

Oliver Watson, Peter Novodvorsky, Caroline Gray, Alexander M K Rothman, Allan Lawrie, David C Crossman, Andrea Haase, Kathryn McMahon, Martin Gering, Fredericus J M Van Eeden, Timothy J A Chico

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35 Citations (Scopus)

Abstract

The contribution of blood flow to angiogenesis is incompletely understood. We examined the effect of blood flow on Notch signalling in the vasculature of zebrafish embryos, and whether blood flow regulates angiogenesis in zebrafish with constitutively up-regulated hypoxic signalling.
Original languageEnglish
Pages (from-to)252-61
Number of pages10
JournalCardiovascular Research
Volume100
Issue number2
DOIs
Publication statusPublished - 1 Nov 2013

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