Brainstem Auditory Evoked Potentials' Diagnostic Accuracy for Hearing Loss: Systematic Review and Meta-Analysis

Parthasarathy D. Thirumala, Gregory Carnovale, Yoon Loke, Miguel E. Habeych, Donald J. Crammond, Jeffrey R. Balzer, Raymond F. Sekula

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)
5 Downloads (Pure)

Abstract

Background: Microvascular decompression (MVD) utilizes brainstem auditory evoked potential (BAEP) intraoperative monitoring to reduce the risk of iatrogenic hearing loss. Studies report varying efficacy and hearing loss rates during MVD with intraoperative monitoring.

Objectives: This study aims to perform a comprehensive review and study of diagnostic accuracy of BAEPs during MVD to predict hearing loss in studies published from January 1984 to December 2013.

Methods: The PubMed/MEDLINE and World Science databases were searched. Studies performed MVD for trigeminal neuralgia, hemifacial spasm, glossopharyngeal neuralgia or geniculate neuralgia and monitored intraoperative BAEPs to prevent hearing loss. Retrospectively, BAEP parameters were compared with postoperative hearing. The diagnostic accuracy of significant change in BAEPs, which includes loss of response, was tested using summary receiver operative curve and diagnostic odds ratio (DOR).

Results: A total of 13 studies were included in the analysis with a total of 2,540 cases. Loss of response pooled sensitivity, specificity, and DOR with 95% confidence interval being 74% (60–84%), 98% (88–100%), and 69.3 (18.2–263%), respectively. The similar significant change results were 88% (77–94%), 63% (40–81%), and 9.1 (3.9–21.6%).

Conclusion: Patients with hearing loss after MVD are more likely to have shown loss of BAEP responses intraoperatively. Loss of responses has high specificity in evaluating hearing loss. Patients undergoing MVD should have BAEP monitoring to prevent hearing loss.
Original languageEnglish
Pages (from-to)043-051
JournalJournal of Neurological Surgery Part B
Volume78
Issue number01
Early online date20 Jun 2016
DOIs
Publication statusPublished - 2017

Keywords

  • evoked potentials
  • auditory
  • brainstem
  • hemifacial spasm
  • trigeminal neuralgia
  • glossopharyngeal nerve diseases
  • hearing loss

Cite this