British Rhinological Society Consensus Guidance on the use of biological therapies for chronic rhinosinusitis with nasal polyps

Claire Hopkins, Jo-Lyn McKenzie, Shahram Anari, Sean Carrie, Yujay Ramakrishnan, Naveed Kara, Carl Philpott, Jonathan Hobson, Ali Qureishi, Ben Stew, Raj Bhalla, Simon Gane, Abigail Walker, Phil Harries

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)
23 Downloads (Pure)


Objectives: We set out to create Consensus Guidelines, based on current evidence and relative risks of adverse effects and the costs of different treatments, which reflect the views of the British Rhinological Society (BRS) Council on where the use of biologics should be positioned within treatment pathways for CRSwNP, specifically in the setting of the National Health Service (NHS). Design: An expert panel of 16 members was assembled. A review of the literature and evidence synthesis was undertaken and circulated to the panel. We used the RAND/UCLA methodology with a multi-step process to make recommendations on the use of biologics. Setting: N/A. Participants: N/A. Results: Recommendations were made, based on underlying disease severity, prior treatments and co-morbidities. A group of patients for whom biologics were considered an appropriate treatment option for CRSwNP was defined. Conclusions: Although biologics are not currently available for the treatment of CRSwNP, the BRS Council have defined a group of patients who have higher rates of “failure” with current treatment pathways, higher resource use and are more likely to suffer with uncontrolled symptoms. We would urge NICE to consider approval of biologics for such indications without applying further restrictions on use.

Original languageEnglish
Pages (from-to)1037-1043
Number of pages7
JournalClinical Otolaryngology
Issue number5
Early online date5 Apr 2021
Publication statusPublished - Sep 2021


  • nasal polyps
  • paranasal sinus disease
  • prevention and control
  • therapeutics

Cite this