(−)-Brunneusine, a new phenolic compound with antibacterial properties in aqueous medium from the leaves of Agelanthus brunneus (Engl.) Tiegh (LORANTHACEAE)

Thomas Wieland Moifo Kuete, Pantaleon Ambassa, Marlyse Luciane Moungang, Bathelemy Ngameni, Thomas E. Storr, Bonaventure Ngadjui Tchaleu, G. Richard Stephenson

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Agelanthus brunneus (Loranthaceae) is a hemiparasitic plant growing on Senna siamea (Fabaceae). The chemical investigation of its leaves and flowers led to the isolation of one new phenolic compound namely (-)-brunneusine (1), together with 13 known compounds. The crude leaves and flowers extracts (CLE and CFLE) with their ethyl acetate fractions (EAFL and EAFFL) and some isolated compounds (1-3; 8-9 and 11-14) have been tested on four bacterial species of sanitary importance isolated in an aquatic environment. All the samples except compound 3 showed antibacterial activity with MICs ranging from 0.43 to 8.88.103 μg/mL and MBCs from 0.43 to 3.55.103 μg/mL. Compounds 9 and 14 showed better activity on all bacterial species tested with MICs ranging from 0.43 to 27.77 μg/mL. Only CLE, EAFL and compounds 14, 2, 8 and 9 showed bactericidal effects on all bacterial species tested.

Original languageEnglish
Pages (from-to)157-165
Number of pages9
JournalZeitschrift für Naturforschung C
Issue number3-4
Early online date28 Sep 2021
Publication statusPublished - Mar 2022


  • Agelanthus brunneus
  • Brunneusine
  • Loranthaceae
  • antibacterial activity

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