TY - JOUR
T1 - (−)-Brunneusine, a new phenolic compound with antibacterial properties in aqueous medium from the leaves of Agelanthus brunneus (Engl.) Tiegh (LORANTHACEAE)
AU - Wieland Moifo Kuete, Thomas
AU - Ambassa, Pantaleon
AU - Luciane Moungang, Marlyse
AU - Ngameni, Bathelemy
AU - Storr, Thomas E.
AU - Ngadjui Tchaleu, Bonaventure
AU - Stephenson , G. Richard
PY - 2022/3
Y1 - 2022/3
N2 - Agelanthus brunneus (Loranthaceae) is a hemiparasitic plant growing on Senna siamea (Fabaceae). The chemical investigation of its leaves and flowers led to the isolation of one new phenolic compound namely (-)-brunneusine (1), together with 13 known compounds. The crude leaves and flowers extracts (CLE and CFLE) with their ethyl acetate fractions (EAFL and EAFFL) and some isolated compounds (1-3; 8-9 and 11-14) have been tested on four bacterial species of sanitary importance isolated in an aquatic environment. All the samples except compound 3 showed antibacterial activity with MICs ranging from 0.43 to 8.88.103 μg/mL and MBCs from 0.43 to 3.55.103 μg/mL. Compounds 9 and 14 showed better activity on all bacterial species tested with MICs ranging from 0.43 to 27.77 μg/mL. Only CLE, EAFL and compounds 14, 2, 8 and 9 showed bactericidal effects on all bacterial species tested.
AB - Agelanthus brunneus (Loranthaceae) is a hemiparasitic plant growing on Senna siamea (Fabaceae). The chemical investigation of its leaves and flowers led to the isolation of one new phenolic compound namely (-)-brunneusine (1), together with 13 known compounds. The crude leaves and flowers extracts (CLE and CFLE) with their ethyl acetate fractions (EAFL and EAFFL) and some isolated compounds (1-3; 8-9 and 11-14) have been tested on four bacterial species of sanitary importance isolated in an aquatic environment. All the samples except compound 3 showed antibacterial activity with MICs ranging from 0.43 to 8.88.103 μg/mL and MBCs from 0.43 to 3.55.103 μg/mL. Compounds 9 and 14 showed better activity on all bacterial species tested with MICs ranging from 0.43 to 27.77 μg/mL. Only CLE, EAFL and compounds 14, 2, 8 and 9 showed bactericidal effects on all bacterial species tested.
KW - Agelanthus brunneus
KW - Brunneusine
KW - Loranthaceae
KW - antibacterial activity
UR - https://www.scopus.com/pages/publications/85116570328
U2 - 10.1515/znc-2021-0143
DO - 10.1515/znc-2021-0143
M3 - Article
SN - 0939-5075
VL - 77
SP - 157
EP - 165
JO - Zeitschrift fur Naturforschung Section C-A Journal of Biosciences
JF - Zeitschrift fur Naturforschung Section C-A Journal of Biosciences
IS - 3-4
ER -