c-Met confers protection against chronic liver tissue damage and fibrosis progression after bile duct ligation in mice

Arne Giebeler; Mark V Boekschoten; Christian Klein; Malgorzata Borowiak; Carmen Birchmeier; Nikolaus Gassler; Hermann E Wasmuth; Michael Müller; Christian Trautwein; Konrad L Streetz

doi:10.1053/j.gastro.2009.01.068

c-Met confers protection against chronic liver tissue damage and fibrosis progression after bile duct ligation in mice

Arne Giebeler, Mark V Boekschoten, Christian Klein, Malgorzata Borowiak, Carmen Birchmeier, Nikolaus Gassler, Hermann E Wasmuth, Michael Müller, Christian Trautwein, Konrad L Streetz

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

Abstract

The hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (c-Met) system is an essential inducer of hepatocyte growth and proliferation. Although a fundamental role for the HGF receptor c-Met has been shown in acute liver regeneration, its cell-specific role in hepatocytes during chronic liver injury and fibrosis progression has not been determined.

Original language	English
Pages (from-to)	297-308
Number of pages	12
Journal	Gastroenterology
Volume	137
Issue number	1
DOIs	https://doi.org/10.1053/j.gastro.2009.01.068
Publication status	Published - Jul 2009

Keywords

Animals
Apoptosis
Cell Proliferation
Cholestasis, Extrahepatic
Chronic Disease
Common Bile Duct
Cytokines
Disease Models, Animal
Disease Progression
Extracellular Matrix Proteins
Gene Expression Profiling
Hepatic Stellate Cells
Hepatitis
Hepatocyte Growth Factor
Hepatocytes
Inflammation Mediators
Ligation
Liver
Liver Cirrhosis
Mice
Mice, Knockout
Necrosis
Neutrophil Infiltration
Oligonucleotide Array Sequence Analysis
Proto-Oncogene Proteins c-met
Time Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1053/j.gastro.2009.01.068

Cite this

@article{36ee9c6110884234873fcbdf4e9bc55c,

title = "c-Met confers protection against chronic liver tissue damage and fibrosis progression after bile duct ligation in mice",

abstract = "The hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (c-Met) system is an essential inducer of hepatocyte growth and proliferation. Although a fundamental role for the HGF receptor c-Met has been shown in acute liver regeneration, its cell-specific role in hepatocytes during chronic liver injury and fibrosis progression has not been determined.",

keywords = "Animals, Apoptosis, Cell Proliferation, Cholestasis, Extrahepatic, Chronic Disease, Common Bile Duct, Cytokines, Disease Models, Animal, Disease Progression, Extracellular Matrix Proteins, Gene Expression Profiling, Hepatic Stellate Cells, Hepatitis, Hepatocyte Growth Factor, Hepatocytes, Inflammation Mediators, Ligation, Liver, Liver Cirrhosis, Mice, Mice, Knockout, Necrosis, Neutrophil Infiltration, Oligonucleotide Array Sequence Analysis, Proto-Oncogene Proteins c-met, Time Factors",

author = "Arne Giebeler and Boekschoten, {Mark V} and Christian Klein and Malgorzata Borowiak and Carmen Birchmeier and Nikolaus Gassler and Wasmuth, {Hermann E} and Michael M{\"u}ller and Christian Trautwein and Streetz, {Konrad L}",

year = "2009",

month = jul,

doi = "10.1053/j.gastro.2009.01.068",

language = "English",

volume = "137",

pages = "297--308",

journal = "Gastroenterology",

issn = "0016-5085",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - c-Met confers protection against chronic liver tissue damage and fibrosis progression after bile duct ligation in mice

AU - Giebeler, Arne

AU - Boekschoten, Mark V

AU - Klein, Christian

AU - Borowiak, Malgorzata

AU - Birchmeier, Carmen

AU - Gassler, Nikolaus

AU - Wasmuth, Hermann E

AU - Müller, Michael

AU - Trautwein, Christian

AU - Streetz, Konrad L

PY - 2009/7

Y1 - 2009/7

N2 - The hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (c-Met) system is an essential inducer of hepatocyte growth and proliferation. Although a fundamental role for the HGF receptor c-Met has been shown in acute liver regeneration, its cell-specific role in hepatocytes during chronic liver injury and fibrosis progression has not been determined.

AB - The hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (c-Met) system is an essential inducer of hepatocyte growth and proliferation. Although a fundamental role for the HGF receptor c-Met has been shown in acute liver regeneration, its cell-specific role in hepatocytes during chronic liver injury and fibrosis progression has not been determined.

KW - Animals

KW - Apoptosis

KW - Cell Proliferation

KW - Cholestasis, Extrahepatic

KW - Chronic Disease

KW - Common Bile Duct

KW - Cytokines

KW - Disease Models, Animal

KW - Disease Progression

KW - Extracellular Matrix Proteins

KW - Gene Expression Profiling

KW - Hepatic Stellate Cells

KW - Hepatitis

KW - Hepatocyte Growth Factor

KW - Hepatocytes

KW - Inflammation Mediators

KW - Ligation

KW - Liver

KW - Liver Cirrhosis

KW - Mice

KW - Mice, Knockout

KW - Necrosis

KW - Neutrophil Infiltration

KW - Oligonucleotide Array Sequence Analysis

KW - Proto-Oncogene Proteins c-met

KW - Time Factors

U2 - 10.1053/j.gastro.2009.01.068

DO - 10.1053/j.gastro.2009.01.068

M3 - Article

C2 - 19208365

VL - 137

SP - 297

EP - 308

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 1

ER -