c-Met confers protection against chronic liver tissue damage and fibrosis progression after bile duct ligation in mice

Arne Giebeler, Mark V Boekschoten, Christian Klein, Malgorzata Borowiak, Carmen Birchmeier, Nikolaus Gassler, Hermann E Wasmuth, Michael Müller, Christian Trautwein, Konrad L Streetz

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

The hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (c-Met) system is an essential inducer of hepatocyte growth and proliferation. Although a fundamental role for the HGF receptor c-Met has been shown in acute liver regeneration, its cell-specific role in hepatocytes during chronic liver injury and fibrosis progression has not been determined.
Original languageEnglish
Pages (from-to)297-308
Number of pages12
JournalGastroenterology
Volume137
Issue number1
DOIs
Publication statusPublished - Jul 2009

Keywords

  • Animals
  • Apoptosis
  • Cell Proliferation
  • Cholestasis, Extrahepatic
  • Chronic Disease
  • Common Bile Duct
  • Cytokines
  • Disease Models, Animal
  • Disease Progression
  • Extracellular Matrix Proteins
  • Gene Expression Profiling
  • Hepatic Stellate Cells
  • Hepatitis
  • Hepatocyte Growth Factor
  • Hepatocytes
  • Inflammation Mediators
  • Ligation
  • Liver
  • Liver Cirrhosis
  • Mice
  • Mice, Knockout
  • Necrosis
  • Neutrophil Infiltration
  • Oligonucleotide Array Sequence Analysis
  • Proto-Oncogene Proteins c-met
  • Time Factors

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