C15 acetogenins with antistaphylococcal activity from the red alga Laurencia glandulifera

Maria Kladi, Constantinos Vagias, Michael Stavri, M. Mukhlesur Rahman, Simon Gibbons, Vassilios Roussis

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Five new C15 eight-membered cyclic ethers (1, 3–6) with a characteristic terminal cis ene–yne moiety, along with the previously reported acetylenic chloro diol (2) were isolated from the organic extract of the red alga Laurencia glandulifera, collected at Crete island in South Greece. Full assignment of all 1H and 13C resonances were carried out by extensive analysis of their NMR spectra. All metabolites were tested for their antistaphylococcal activity and the minimum inhibitory concentrations (MICs) of 2–5 were in the range of 8–256 μg/ml.
Original languageEnglish
Pages (from-to)31-36
Number of pages6
JournalPhytochemistry Letters
Issue number1
Early online date21 Feb 2008
Publication statusPublished - 15 Apr 2008

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