CA3 size predicts the precision of memory recall

Martin J Chadwick, Heidi M Bonnici, Eleanor A Maguire

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

There is enduring interest in why some of us have clearer memories than others, given the substantial individual variation that exists in retrieval ability and the precision with which we can differentiate past experiences. Here we report novel evidence showing that variation in the size of human hippocampal subfield CA3 predicted the amount of neural interference between episodic memories within CA3, which in turn predicted how much retrieval confusion occurred between past memories. This effect was not apparent in other hippocampal subfields. This shows that subtle individual differences in subjective mnemonic experience can be accurately gauged from measurable variations in the anatomy and neural coding of hippocampal region CA3. Moreover, this mechanism may be relevant for understanding memory muddles in aging and pathological states.
Original languageEnglish
Pages (from-to)10720-10725
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America (PNAS)
Volume111
Issue number29
DOIs
Publication statusPublished - 22 Jul 2014

Keywords

  • Adolescent
  • Adult
  • CA3 Region, Hippocampal
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Mental Recall
  • Models, Neurological
  • Organ Size
  • Photic Stimulation
  • Young Adult

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