Abstract
Plasma lipoprotein levels are determined by the balance between lipoprotein production and clearance. Recently, angiopoietin-like protein 4 (ANGPTL4) was uncovered as a novel endocrine factor that potently raises plasma triglyceride levels by inhibiting triglyceride clearance. However, very little is known about ANGPTL4 in human. Here we set out to identify physiological determinants of plasma ANGPTL4 levels in humans, focusing on the effect of energy restriction and plasma FFAs.
| Original language | English |
|---|---|
| Pages (from-to) | 969-974 |
| Number of pages | 6 |
| Journal | Arteriosclerosis, Thrombosis, and Vascular Biology |
| Volume | 29 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2009 |
Keywords
- Adrenergic beta-Agonists
- Adult
- Albuterol
- Angiopoietins
- Animals
- Caloric Restriction
- Cells, Cultured
- Enzyme-Linked Immunosorbent Assay
- Exercise
- Fat Emulsions, Intravenous
- Fatty Acids, Nonesterified
- Humans
- Hypolipidemic Agents
- Intestines
- Liver Neoplasms
- Male
- Mice
- Middle Aged
- Myocytes, Cardiac
- RNA, Messenger
- Rats
- Time Factors
- Transfection
- Up-Regulation
- Young Adult