Caloric restriction and exercise increase plasma ANGPTL4 levels in humans via elevated free fatty acids

Sander Kersten, Laeticia Lichtenstein, Emma Steenbergen, Karin Mudde, Henk F J Hendriks, Matthijs K Hesselink, Patrick Schrauwen, Michael Müller

Research output: Contribution to journalArticlepeer-review

171 Citations (Scopus)


Plasma lipoprotein levels are determined by the balance between lipoprotein production and clearance. Recently, angiopoietin-like protein 4 (ANGPTL4) was uncovered as a novel endocrine factor that potently raises plasma triglyceride levels by inhibiting triglyceride clearance. However, very little is known about ANGPTL4 in human. Here we set out to identify physiological determinants of plasma ANGPTL4 levels in humans, focusing on the effect of energy restriction and plasma FFAs.
Original languageEnglish
Pages (from-to)969-974
Number of pages6
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Issue number6
Publication statusPublished - Jun 2009


  • Adrenergic beta-Agonists
  • Adult
  • Albuterol
  • Angiopoietins
  • Animals
  • Caloric Restriction
  • Cells, Cultured
  • Enzyme-Linked Immunosorbent Assay
  • Exercise
  • Fat Emulsions, Intravenous
  • Fatty Acids, Nonesterified
  • Humans
  • Hypolipidemic Agents
  • Intestines
  • Liver Neoplasms
  • Male
  • Mice
  • Middle Aged
  • Myocytes, Cardiac
  • RNA, Messenger
  • Rats
  • Time Factors
  • Transfection
  • Up-Regulation
  • Young Adult

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