Can we measure catalyst efficiency in asymmetric chemical reactions? A theoretical approach

Shaimaa El-Fayyoumy; Matthew H. Todd; Christopher J. Richards

doi:10.3762/bjoc.5.67

Can we measure catalyst efficiency in asymmetric chemical reactions? A theoretical approach

Shaimaa El-Fayyoumy, Matthew H. Todd, Christopher J. Richards

Chemistry of Materials and Catalysis

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The discovery that palladacycles are efficient catalysts for the allylic imidate rearrangement has resulted in the successful application of several such complexes to this reaction based on planar chiral iron and cobalt containing metallocenes. These palladacycles enable the efficient and highly enantioselective synthesis of a wide variety of protected allylic amines, which are valuable building blocks for use in asymmetric synthesis.

Original language	English
Pages (from-to)	1726-1740
Number of pages	15
Journal	Beilstein Journal of Organic Chemistry
Volume	5
Issue number	8
DOIs	https://doi.org/10.3762/bjoc.5.67
Publication status	Published - 2009

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10.3762/bjoc.5.67

Cite this

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title = "Can we measure catalyst efficiency in asymmetric chemical reactions? A theoretical approach",

abstract = "The discovery that palladacycles are efficient catalysts for the allylic imidate rearrangement has resulted in the successful application of several such complexes to this reaction based on planar chiral iron and cobalt containing metallocenes. These palladacycles enable the efficient and highly enantioselective synthesis of a wide variety of protected allylic amines, which are valuable building blocks for use in asymmetric synthesis.",

author = "Shaimaa El-Fayyoumy and Todd, {Matthew H.} and Richards, {Christopher J.}",

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AU - El-Fayyoumy, Shaimaa

AU - Todd, Matthew H.

AU - Richards, Christopher J.

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Y1 - 2009

N2 - The discovery that palladacycles are efficient catalysts for the allylic imidate rearrangement has resulted in the successful application of several such complexes to this reaction based on planar chiral iron and cobalt containing metallocenes. These palladacycles enable the efficient and highly enantioselective synthesis of a wide variety of protected allylic amines, which are valuable building blocks for use in asymmetric synthesis.

AB - The discovery that palladacycles are efficient catalysts for the allylic imidate rearrangement has resulted in the successful application of several such complexes to this reaction based on planar chiral iron and cobalt containing metallocenes. These palladacycles enable the efficient and highly enantioselective synthesis of a wide variety of protected allylic amines, which are valuable building blocks for use in asymmetric synthesis.

U2 - 10.3762/bjoc.5.67

DO - 10.3762/bjoc.5.67

M3 - Article

VL - 5

SP - 1726

EP - 1740

JO - Beilstein Journal of Organic Chemistry

JF - Beilstein Journal of Organic Chemistry

SN - 1860-5397

IS - 8

ER -