Carbapenem-resistant Escherichia coli and Klebsiella pneumoniae isolates from Turkey with OXA-48-like carbapenemases and outer membrane protein loss

Dolunay Gülmez, Neil Woodford, Marie-France I Palepou, Shazad Mushtaq, Gokhan Metan, Yusuf Yakupogullari, Sesin Kocagoz, Omrum Uzun, Gulsen Hascelik, David M Livermore

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Abstract

Treatment options are limited in infections caused by extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae, with carbapenems generally preferred. Disturbingly, however, carbapenem-resistant strains are emerging worldwide. Here we report two clinical isolates, one Escherichia coli and one Klebsiella pneumoniae, each with high-level carbapenem resistance (imipenem minimum inhibitory concentration of 32 microg/mL). They were isolated following imipenem therapy from two hospital patients who had received imipenem therapy in different regions of Turkey. Both isolates produced OXA-48-like carbapenemases, enzymes so far reported only from Turkey. Both isolates also had group 1 CTX-M-type ESBLs and had lost major outer membrane proteins. OXA-48-like carbapenemases appear to be scattered in Turkey and surveillance to determine their prevalence is warranted.
Original languageEnglish
Pages (from-to)523-6
Number of pages4
JournalInternational Journal of Antimicrobial Agents
Volume31
Issue number6
DOIs
Publication statusPublished - Jun 2008

Keywords

  • Anti-Bacterial Agents
  • Bacterial Outer Membrane Proteins
  • Carbapenems
  • DNA, Bacterial
  • Drug Resistance, Bacterial
  • Escherichia coli
  • Escherichia coli Infections
  • Female
  • Humans
  • Klebsiella Infections
  • Klebsiella pneumoniae
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Porins
  • Reverse Transcriptase Polymerase Chain Reaction
  • Transformation, Bacterial
  • Turkey
  • beta-Lactam Resistance
  • beta-Lactamases
  • beta-Lactams

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