Cardiac energetic impairment in heart disease and the potential role of metabolic modulators: A review for clinicians

Satnam Singh; Konstantin Schwarz; John Horowitz; Michael Frenneaux

doi:10.1161/CIRCGENETICS.114.000221

Cardiac energetic impairment in heart disease and the potential role of metabolic modulators: A review for clinicians

Satnam Singh, Konstantin Schwarz, John Horowitz, Michael Frenneaux

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Cardiac energetic impairment is a frequent finding in patients with both inherited and acquired diseases of heart muscle. In this review the mechanisms of energy generation in the healthy heart and their disturbances in heart muscle diseases are described. Therapeutic agents targeted at correcting cardiac energetic impairment are discussed.

Original language	English
Pages (from-to)	720-728
Number of pages	9
Journal	Circulation: Cardiovascular Genetics
Volume	7
Issue number	5
DOIs	https://doi.org/10.1161/CIRCGENETICS.114.000221
Publication status	Published - 1 Oct 2014

Keywords

drug therapy
energy metabolism
perhexiline
reperfusion injury

Access to Document

10.1161/CIRCGENETICS.114.000221

Cite this

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title = "Cardiac energetic impairment in heart disease and the potential role of metabolic modulators: A review for clinicians",

abstract = "Cardiac energetic impairment is a frequent finding in patients with both inherited and acquired diseases of heart muscle. In this review the mechanisms of energy generation in the healthy heart and their disturbances in heart muscle diseases are described. Therapeutic agents targeted at correcting cardiac energetic impairment are discussed.",

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AB - Cardiac energetic impairment is a frequent finding in patients with both inherited and acquired diseases of heart muscle. In this review the mechanisms of energy generation in the healthy heart and their disturbances in heart muscle diseases are described. Therapeutic agents targeted at correcting cardiac energetic impairment are discussed.

KW - drug therapy

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KW - perhexiline

KW - reperfusion injury

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