Cardiac T1 Mapping and Extracellular Volume (ECV) in clinical practice: a comprehensive review

Philip Haaf, Pankaj Garg, Daniel R. Messroghli, David A. Broadbent, John P. Greenwood, Sven Plein

Research output: Contribution to journalArticlepeer-review

260 Citations (Scopus)

Abstract

Cardiovascular Magnetic Resonance is increasingly used to differentiate the aetiology of cardiomyopathies. Late Gadolinium Enhancement (LGE) is the reference standard for non-invasive imaging of myocardial scar and focal fibrosis and is valuable in the differential diagnosis of ischaemic versus non-ischaemic cardiomyopathy. Diffuse fibrosis may go undetected on LGE imaging. Tissue characterisation with parametric mapping methods has the potential to detect and quantify both focal and diffuse alterations in myocardial structure not assessable by LGE. Native and post-contrast T1 mapping in particular has shown promise as a novel biomarker to support diagnostic, therapeutic and prognostic decision making in ischaemic and non-ischaemic cardiomyopathies as well as in patients with acute chest pain syndromes. Furthermore, changes in the myocardium over time may be assessed longitudinally with this non-invasive tissue characterisation method.
Original languageEnglish
Article number89
JournalJournal of Cardiovascular Magnetic Resonance
Volume18
Issue number1
Early online date30 Nov 2016
DOIs
Publication statusPublished - 1 Jan 2017

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