Cardiovascular magnetic resonance determinants of left ventricular noncompaction

Dana K Dawson, David J McLernon, Vimal J Raj, Alicia M Maceira, Sanjay Prasad, Michael P Frenneaux, Dudley J Pennell, Philip J Kilner

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Insufficient precision remains in accurately identifying left ventricular noncompaction (LVNC) from the healthy normal morphologic spectrum. We aim to provide a better distinction between normal left ventricular trabeculations and LVNC. We used a previously well-defined cohort of 120 healthy volunteers for normal reference values of the trabecular/compacted ratio derived from a consistent selection of short-axis cardiovascular magnetic resonance images. We performed forward selection of logistic regression models, selecting the best model that was subsequently assessed for discrimination and calibration, validated, and converted into a clinical diagnostic chart to benchmark the boundaries of detection from a cohort of 30 patients considered to have LVNC. We showed that 3 combinations of a maximal end-diastolic trabecular/compacted ratio (≥1 [apex], >1.8 [midcavity]), (>2 [apex], ≥0.6 [midcavity]), or (>0.5 [base], >1.8 [midcavity]) separate the cohorts with the highest accuracy (C statistic [95% confidence interval] of 0.9749 (0.9748 to 0.9751) for the diagnostic chart). Quantitative cardiovascular magnetic resonance also shows that patients considered to have LVNC have a significantly reduced ejection fraction compared with normal volunteers. At midcavity and apical level, it is difficult to identify papillary muscles that are replaced by a dense trabecular meshwork. In conclusion, we developed a new, refined, diagnostic tool for identifying LVNC, based on an a priori assessment of the trabecular architecture in healthy volunteers.
Original languageEnglish
Pages (from-to)456-462
Number of pages7
JournalThe American Journal of Cardiology
Issue number3
Publication statusPublished - 1 Aug 2014


  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Healthy Volunteers
  • Heart Ventricles
  • Humans
  • Isolated Noncompaction of the Ventricular Myocardium
  • Magnetic Resonance Imaging, Cine
  • Male
  • Middle Aged
  • Reproducibility of Results
  • Young Adult

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