Projects per year
Abstract
Anthocyanins are reported to have cardio-protective effects, although their mechanisms of action remain elusive. We aimed to explore the effects of microbial metabolites common to anthocyanins and other flavonoids on vascular smooth muscle heme oxygenase-1 (HO-1) expression. Thirteen phenolic metabolites identified by previous anthocyanin human feeding studies, as well as 28 unique mixtures of metabolites and their known precursor structures were explored for their activity on HO-1 protein expression in rat aortic smooth muscle cells (RASMCs). No phenolic metabolites were active when treated in isolation; however, five mixtures of phenolic metabolites significantly increased HO-1 protein expression (127.4-116.6%, p ≤ 0.03). The present study demonstrates that phenolic metabolites of anthocyanins differentially affect HO-1 activity, often having additive, synergistic or nullifying effects.
Original language | English |
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Article number | 898 |
Journal | Molecules |
Volume | 23 |
Issue number | 4 |
DOIs | |
Publication status | Published - 13 Apr 2018 |
Profiles
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Maria O'Connell
- Faculty of Science - Associate Dean for Research
- School of Chemistry, Pharmacy and Pharmacology - Professor of Cell Biology
- Molecular and Tissue Pharmacology - Group Lead
- HealthUEA - Steering Committee Member
Person: Research Group Member, Academic, Teaching & Research
Projects
- 1 Finished
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The collective bioactivity of dietary flavonoids: importance of specific structural characteristics for cardiovascular benefits
Kay, C., Cassidy, A. & O'Connell, M.
Biotechnology and Biological Sciences Research Council
28/03/11 → 27/03/14
Project: Research