Catch-up growth following intra-uterine growth-restriction programmes an insulin-resistant phenotype in adipose tissue

L M Berends, D S Fernandez-Twinn, M S Martin-Gronert, R L Cripps, S E Ozanne

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78 Citations (Scopus)

Abstract

It is now widely accepted that the early-life nutritional environment is important in determining susceptibility to metabolic diseases. In particular, intra-uterine growth restriction followed by accelerated postnatal growth is associated with an increased risk of obesity, type-2 diabetes and other features of the metabolic syndrome. The mechanisms underlying these observations are not fully understood.
Original languageEnglish
Pages (from-to)1051-1057
Number of pages7
JournalInternational Journal of Obesity
Volume37
Issue number8
DOIs
Publication statusPublished - Aug 2013

Keywords

  • developmental programming
  • maternal under-nutrition
  • catch-up growth
  • adipose tissue
  • insulin resistance
  • type-2 diabetes

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