TY - JOUR
T1 - Causes of musculoskeletal pain in Paget’s disease of bone
AU - Berg, Kathryn
AU - Dockrell, Dervil
AU - Colvin, Lesley
AU - Fraser, William D.
AU - Tang, Jonathan C. Y.
AU - Aspray, Terry
AU - Dennison, Elaine
AU - Divyateja, Hrushikesh
AU - Ghouri, Nazim
AU - Hanison, Esther
AU - Keen, Richard
AU - McCloskey, Eugene
AU - O'Neill, Terence W.
AU - Rahman, Faizanur
AU - Siddiqi, Mashood
AU - Tuck, Stephen
AU - Turton, Jane
AU - Ralston, Stuart H.
N1 - Funding information: This research was supported in part by a grant to Stuart H Ralston, Lesley Colvin, and William D Fraser by the Paget’s Association (UK) and by a research bursary to Kathryn Berg from the Paget’s Association (UK). The research leading to these results has received funding from the European Research Council under the European Union’s Horizon 2020 Framework Programme (787270-Paget-Advance). Open access funding was provided by the University of Edinburgh.
PY - 2024/11
Y1 - 2024/11
N2 - Paget’s disease of bone (PDB) is characterised by increased and disorganised bone remodelling leading to various complications, such as bone deformity, deafness, secondary osteoarthritis, and pathological fracture. Pain is the most common presenting symptom of PDB, but it is unclear to what extent this is due to increased metabolic activity of the disease, complications, or unrelated causes. We conducted a cross-sectional study of 168 people with PDB attending secondary care referral centres in the UK. We documented the presence of musculoskeletal pain and sought to determine its underlying causes. Musculoskeletal pain was reported by 122/168 (72.6%) individuals. The most common cause was osteoarthritis of joints distant from an affected PDB site in 54 (44.3%), followed by metabolically active PDB in 18 (14.7%); bone deformity in 14 (11.4%); osteoarthritis of a joint neighbouring an affected site in 11 (9.0%), neuropathic pain in 10 (8.2%), and various other causes in the remainder. Pain was more common in women (p
AB - Paget’s disease of bone (PDB) is characterised by increased and disorganised bone remodelling leading to various complications, such as bone deformity, deafness, secondary osteoarthritis, and pathological fracture. Pain is the most common presenting symptom of PDB, but it is unclear to what extent this is due to increased metabolic activity of the disease, complications, or unrelated causes. We conducted a cross-sectional study of 168 people with PDB attending secondary care referral centres in the UK. We documented the presence of musculoskeletal pain and sought to determine its underlying causes. Musculoskeletal pain was reported by 122/168 (72.6%) individuals. The most common cause was osteoarthritis of joints distant from an affected PDB site in 54 (44.3%), followed by metabolically active PDB in 18 (14.7%); bone deformity in 14 (11.4%); osteoarthritis of a joint neighbouring an affected site in 11 (9.0%), neuropathic pain in 10 (8.2%), and various other causes in the remainder. Pain was more common in women (p
KW - Macrophage colony stimulating factor
KW - Osteoarthritis
KW - Paget's Disease of bone
KW - Pain
UR - http://www.scopus.com/inward/record.url?scp=85205355247&partnerID=8YFLogxK
U2 - 10.1007/s00223-024-01279-0
DO - 10.1007/s00223-024-01279-0
M3 - Article
SN - 0171-967X
VL - 115
SP - 533
EP - 541
JO - Calcified Tissue International
JF - Calcified Tissue International
IS - 5
ER -