Cell cycle control of replication initiation in eukaryotes

Stephane Chevalier, J. Julian Blow

Research output: Contribution to journalArticlepeer-review


Studies on the initiation of DNA replication in eukaryotes have progressed recently through different approaches that promise to converge. Proteins interacting with the origin recognition complex form a prereplicative complex early in the cell cycle. The regulation of the binding of MCM/P1 proteins to chromatin plays a key role in the replication licensing system which prevents re-replication in a single cell cycle. Cyclin-dependent kinases provide an overall control of the cell cycle by stimulating S-phase entry and possibly by preventing re-establishment of prereplicative complexes in G2 phase.
Original languageEnglish
Pages (from-to)815-821
Number of pages7
JournalCurrent Opinion in Cell Biology
Issue number6
Publication statusPublished - Dec 1996

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