Cellular Uptake of a Fluorescent Calix[4]arene Derivative

R Lalor, H Baillie-Johnson, C Redshaw, SE Matthews, A Mueller

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Abstract

A rapid synthetic route to a nontoxic fluorescently labeled water-soluble calixarene has been developed. Investigation of the cellular uptake of the labeled calixarene, via confocal microscopy, through coincubation with uptake inhibitors demonstrates that uptake is not through the common clathrin coated pits or caveolae (lipid raft) endocytic pathways and that the calixarene derivative localizes within the cytoplasm and does not enter the nucleus. The study demonstrates the power of fluorescent labeling for investigation of interactions between calixarenes and biological systems and the potential for calixarene based intracellular imaging agents.
Original languageEnglish
Pages (from-to)2892-2893
Number of pages2
JournalJournal of the American Chemical Society
Volume130
Issue number10
DOIs
Publication statusPublished - 16 Feb 2008

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