Cellular uptake of a fluorescent vanadyl sulfonylcalix[4]arene

Carl Redshaw; Mark R. J. Elsegood; Joseph A. Wright; Hugo Baillie-Johnson; Takehiko Yamato; Stephen De Giovanni; Anja Mueller

doi:10.1039/C2CC16480A

Cellular uptake of a fluorescent vanadyl sulfonylcalix[4]arene

Carl Redshaw, Mark R. J. Elsegood, Joseph A. Wright, Hugo Baillie-Johnson, Takehiko Yamato, Stephen De Giovanni, Anja Mueller

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Vanadyl bearing calix[4]arene ligands have undergone evaluation against several cell lines, and show varying degrees of toxicity. For vanadyl complexed to a sulfonylcalix[4]arene, monitoring of the strong blue fluorescence revealed slow uptake kinetics. The complex is exclusively found in the cytoplasm of the cells and uptake is not due to active endocytotic mechanisms.

Original language	English
Pages (from-to)	1129-1131
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	8
DOIs	https://doi.org/10.1039/C2CC16480A
Publication status	Published - 28 Jan 2012

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10.1039/C2CC16480A

Cite this

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title = "Cellular uptake of a fluorescent vanadyl sulfonylcalix[4]arene",

abstract = "Vanadyl bearing calix[4]arene ligands have undergone evaluation against several cell lines, and show varying degrees of toxicity. For vanadyl complexed to a sulfonylcalix[4]arene, monitoring of the strong blue fluorescence revealed slow uptake kinetics. The complex is exclusively found in the cytoplasm of the cells and uptake is not due to active endocytotic mechanisms.",

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AU - Elsegood, Mark R. J.

AU - Wright, Joseph A.

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AU - Yamato, Takehiko

AU - De Giovanni, Stephen

AU - Mueller, Anja

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AB - Vanadyl bearing calix[4]arene ligands have undergone evaluation against several cell lines, and show varying degrees of toxicity. For vanadyl complexed to a sulfonylcalix[4]arene, monitoring of the strong blue fluorescence revealed slow uptake kinetics. The complex is exclusively found in the cytoplasm of the cells and uptake is not due to active endocytotic mechanisms.

U2 - 10.1039/C2CC16480A

DO - 10.1039/C2CC16480A

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JO - Chemical Communications

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