Challenges in the development of heteromer-GPCR-based drugs

Rafael Franco, Eva Martínez-Pinilla, Ana Ricobaraza, Peter J. McCormick

Research output: Chapter in Book/Report/Conference proceedingChapter


G-protein-coupled receptors are targets of a variety of diseases. Drug screening has been classically performed assuming the occurrence of monomeric receptors. As more and more receptor heteromers are identified, the challenge is now to develop screening assays to select heteromer-specific drugs. These drugs may, for instance, be able to interact preferentially with prerather than with postsynaptic receptors. Heteromer-based drug discovery opens new perspectives in both Academic pursuits and for the Pharmaceutical industry.
Original languageEnglish
Title of host publicationProgress in Molecular Biology and Translational Science
Number of pages20
Publication statusPublished - 1 Jan 2013

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