TY - CHAP
T1 - Challenges in the development of heteromer-GPCR-based drugs
AU - Franco, Rafael
AU - Martínez-Pinilla, Eva
AU - Ricobaraza, Ana
AU - McCormick, Peter J.
PY - 2013/1/1
Y1 - 2013/1/1
N2 - G-protein-coupled receptors are targets of a variety of diseases. Drug screening has been classically performed assuming the occurrence of monomeric receptors. As more and more receptor heteromers are identified, the challenge is now to develop screening assays to select heteromer-specific drugs. These drugs may, for instance, be able to interact preferentially with prerather than with postsynaptic receptors. Heteromer-based drug discovery opens new perspectives in both Academic pursuits and for the Pharmaceutical industry.
AB - G-protein-coupled receptors are targets of a variety of diseases. Drug screening has been classically performed assuming the occurrence of monomeric receptors. As more and more receptor heteromers are identified, the challenge is now to develop screening assays to select heteromer-specific drugs. These drugs may, for instance, be able to interact preferentially with prerather than with postsynaptic receptors. Heteromer-based drug discovery opens new perspectives in both Academic pursuits and for the Pharmaceutical industry.
UR - http://www.scopus.com/inward/record.url?scp=84880860153&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-386931-9.00006-4
DO - 10.1016/B978-0-12-386931-9.00006-4
M3 - Chapter
AN - SCOPUS:84880860153
SN - 9780123869319
VL - 117
SP - 143
EP - 162
BT - Progress in Molecular Biology and Translational Science
ER -