Changes in pulmonary vascular function after acute methionine loading in normal men

Conor O'Dochartaigh, Hean Ong, Sharon Lovell, Ronan Donnelly, Colm Hanratty, Marshall Riley, Michael Frenneaux, Ian Young, Paul Nicholls

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Elevated blood levels of Hcy (homocysteine) are associated with endothelial dysfunction in the systemic and coronary arterial beds. We wished to know if similar changes could be detected in the pulmonary circulation, using non-invasive tests. We studied ten normal young men aged 23-31 years, in whom acute hyperhomocysteinaemia was induced by oral ingestion of methionine. Cardiopulmonary exercise testing [including measurement of exhaled breath NO (nitric oxide)] was performed on two occasions, with and without methionine loading. In addition, blood samples for vWf (von Willebrand factor) and factor VIIIc were taken as markers of endothelial function. After oral methionine, plasma Hcy increased from 11.8 +/- 3.1 to 31.2 +/- 10.3 micromol/l (values are means +/- S.D.; P
Original languageEnglish
Pages (from-to)413-419
Number of pages7
JournalClinical Science
Issue number4
Publication statusPublished - Apr 2004


  • Adult
  • Biological Markers
  • Breath Tests
  • Endothelium, Vascular
  • Exercise Test
  • Factor VIII
  • Humans
  • Hyperhomocysteinemia
  • Male
  • Methionine
  • Nitric Oxide
  • Pulmonary Circulation
  • Pulmonary Gas Exchange
  • von Willebrand Factor

Cite this