Changes in pulmonary vascular function after acute methionine loading in normal men

Conor O'Dochartaigh; Hean Ong; Sharon Lovell; Ronan Donnelly; Colm Hanratty; Marshall Riley; Michael Frenneaux; Ian Young; Paul Nicholls

doi:10.1042/CS20030383

Changes in pulmonary vascular function after acute methionine loading in normal men

Conor O'Dochartaigh, Hean Ong, Sharon Lovell, Ronan Donnelly, Colm Hanratty, Marshall Riley, Michael Frenneaux, Ian Young, Paul Nicholls

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Elevated blood levels of Hcy (homocysteine) are associated with endothelial dysfunction in the systemic and coronary arterial beds. We wished to know if similar changes could be detected in the pulmonary circulation, using non-invasive tests. We studied ten normal young men aged 23-31 years, in whom acute hyperhomocysteinaemia was induced by oral ingestion of methionine. Cardiopulmonary exercise testing [including measurement of exhaled breath NO (nitric oxide)] was performed on two occasions, with and without methionine loading. In addition, blood samples for vWf (von Willebrand factor) and factor VIIIc were taken as markers of endothelial function. After oral methionine, plasma Hcy increased from 11.8 +/- 3.1 to 31.2 +/- 10.3 micromol/l (values are means +/- S.D.; P

Original language	English
Pages (from-to)	413-419
Number of pages	7
Journal	Clinical Science
Volume	106
Issue number	4
DOIs	https://doi.org/10.1042/CS20030383
Publication status	Published - Apr 2004

Keywords

Adult
Biological Markers
Breath Tests
Endothelium, Vascular
Exercise Test
Factor VIII
Humans
Hyperhomocysteinemia
Male
Methionine
Nitric Oxide
Pulmonary Circulation
Pulmonary Gas Exchange
von Willebrand Factor

Access to Document

10.1042/CS20030383

Cite this

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title = "Changes in pulmonary vascular function after acute methionine loading in normal men",

abstract = "Elevated blood levels of Hcy (homocysteine) are associated with endothelial dysfunction in the systemic and coronary arterial beds. We wished to know if similar changes could be detected in the pulmonary circulation, using non-invasive tests. We studied ten normal young men aged 23-31 years, in whom acute hyperhomocysteinaemia was induced by oral ingestion of methionine. Cardiopulmonary exercise testing [including measurement of exhaled breath NO (nitric oxide)] was performed on two occasions, with and without methionine loading. In addition, blood samples for vWf (von Willebrand factor) and factor VIIIc were taken as markers of endothelial function. After oral methionine, plasma Hcy increased from 11.8 +/- 3.1 to 31.2 +/- 10.3 micromol/l (values are means +/- S.D.; P ",

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author = "Conor O'Dochartaigh and Hean Ong and Sharon Lovell and Ronan Donnelly and Colm Hanratty and Marshall Riley and Michael Frenneaux and Ian Young and Paul Nicholls",

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T1 - Changes in pulmonary vascular function after acute methionine loading in normal men

AU - O'Dochartaigh, Conor

AU - Ong, Hean

AU - Lovell, Sharon

AU - Donnelly, Ronan

AU - Hanratty, Colm

AU - Riley, Marshall

AU - Frenneaux, Michael

AU - Young, Ian

AU - Nicholls, Paul

PY - 2004/4

Y1 - 2004/4

N2 - Elevated blood levels of Hcy (homocysteine) are associated with endothelial dysfunction in the systemic and coronary arterial beds. We wished to know if similar changes could be detected in the pulmonary circulation, using non-invasive tests. We studied ten normal young men aged 23-31 years, in whom acute hyperhomocysteinaemia was induced by oral ingestion of methionine. Cardiopulmonary exercise testing [including measurement of exhaled breath NO (nitric oxide)] was performed on two occasions, with and without methionine loading. In addition, blood samples for vWf (von Willebrand factor) and factor VIIIc were taken as markers of endothelial function. After oral methionine, plasma Hcy increased from 11.8 +/- 3.1 to 31.2 +/- 10.3 micromol/l (values are means +/- S.D.; P

AB - Elevated blood levels of Hcy (homocysteine) are associated with endothelial dysfunction in the systemic and coronary arterial beds. We wished to know if similar changes could be detected in the pulmonary circulation, using non-invasive tests. We studied ten normal young men aged 23-31 years, in whom acute hyperhomocysteinaemia was induced by oral ingestion of methionine. Cardiopulmonary exercise testing [including measurement of exhaled breath NO (nitric oxide)] was performed on two occasions, with and without methionine loading. In addition, blood samples for vWf (von Willebrand factor) and factor VIIIc were taken as markers of endothelial function. After oral methionine, plasma Hcy increased from 11.8 +/- 3.1 to 31.2 +/- 10.3 micromol/l (values are means +/- S.D.; P

KW - Adult

KW - Biological Markers

KW - Breath Tests

KW - Endothelium, Vascular

KW - Exercise Test

KW - Factor VIII

KW - Humans

KW - Hyperhomocysteinemia

KW - Male

KW - Methionine

KW - Nitric Oxide

KW - Pulmonary Circulation

KW - Pulmonary Gas Exchange

KW - von Willebrand Factor

U2 - 10.1042/CS20030383

DO - 10.1042/CS20030383

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JO - Clinical Science

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SN - 0143-5221

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