Changes in the organization of excitation-contraction coupling structures in failing human heart

David J. Crossman, Peter R. Ruygrok, Christian Soeller, Mark B. Cannell

Research output: Contribution to journalArticlepeer-review

127 Citations (Scopus)


The cardiac myocyte t-tubular system ensures rapid, uniform cell activation and several experimental lines of evidence suggest changes in the t-tubular system and associated excitation-contraction coupling proteins may occur in heart failure.
Original languageEnglish
Article numbere17901
JournalPLoS One
Issue number3
Publication statusPublished - 9 Mar 2011


  • Actin Cytoskeleton
  • Aged
  • Calcium Channels, L-Type
  • Excitation Contraction Coupling
  • Heart Failure
  • Humans
  • Magnetic Resonance Imaging
  • Middle Aged
  • Myocytes, Cardiac
  • Ryanodine Receptor Calcium Release Channel
  • Sarcolemma
  • Sarcoplasmic Reticulum
  • Staining and Labeling
  • Wheat Germ Agglutinins

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