Changes in the organization of excitation-contraction coupling structures in failing human heart

David J. Crossman; Peter R. Ruygrok; Christian Soeller; Mark B. Cannell

doi:10.1371/journal.pone.0017901

Changes in the organization of excitation-contraction coupling structures in failing human heart

David J. Crossman, Peter R. Ruygrok, Christian Soeller, Mark B. Cannell

Research output: Contribution to journal › Article › peer-review

134 Citations (Scopus)

Abstract

The cardiac myocyte t-tubular system ensures rapid, uniform cell activation and several experimental lines of evidence suggest changes in the t-tubular system and associated excitation-contraction coupling proteins may occur in heart failure.

Original language	English
Article number	e17901
Journal	PLoS One
Volume	6
Issue number	3
DOIs	https://doi.org/10.1371/journal.pone.0017901
Publication status	Published - 9 Mar 2011

Keywords

Actin Cytoskeleton
Aged
Calcium Channels, L-Type
Excitation Contraction Coupling
Heart Failure
Humans
Magnetic Resonance Imaging
Middle Aged
Myocytes, Cardiac
Ryanodine Receptor Calcium Release Channel
Sarcolemma
Sarcoplasmic Reticulum
Staining and Labeling
Wheat Germ Agglutinins

Access to Document

10.1371/journal.pone.0017901Licence: CC BY

Cite this

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title = "Changes in the organization of excitation-contraction coupling structures in failing human heart",

abstract = "The cardiac myocyte t-tubular system ensures rapid, uniform cell activation and several experimental lines of evidence suggest changes in the t-tubular system and associated excitation-contraction coupling proteins may occur in heart failure.",

keywords = "Actin Cytoskeleton, Aged, Calcium Channels, L-Type, Excitation Contraction Coupling, Heart Failure, Humans, Magnetic Resonance Imaging, Middle Aged, Myocytes, Cardiac, Ryanodine Receptor Calcium Release Channel, Sarcolemma, Sarcoplasmic Reticulum, Staining and Labeling, Wheat Germ Agglutinins",

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AU - Ruygrok, Peter R.

AU - Soeller, Christian

AU - Cannell, Mark B.

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KW - Excitation Contraction Coupling

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KW - Magnetic Resonance Imaging

KW - Middle Aged

KW - Myocytes, Cardiac

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KW - Sarcolemma

KW - Sarcoplasmic Reticulum

KW - Staining and Labeling

KW - Wheat Germ Agglutinins

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