Characterization of a t(8;13)(p11;q11-12) in an atypical myeloproliferative disorder

Damian Smedley; Gino Somers; Deon Venter; Chung Wo Chow; Colin Cooper; Janet Shipley

doi:10.1002/(SICI)1098-2264(199801)21:1<70::AID-GCC9>3.0.CO;2-5

Characterization of a t(8;13)(p11;q11-12) in an atypical myeloproliferative disorder

Damian Smedley, Gino Somers, Deon Venter, Chung Wo Chow, Colin Cooper, Janet Shipley

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Fourteen cases of an atypical myeloproliferative disorder associated with consistent translocations involving 8p11-12 have previously been described. A t(8;13)(p11;q11-12) was the most common, but variant t(8;9)(p11- 12;q32-34) and t(6;8)(q27;p12) were also reported. Here we have used a series of yeast artificial chromosomes (YACs) derived from the 8p11 and 13q11-12 regions to analyse one of the t(8;13) cases by fluorescence in situ hybridization (FISH). YACs flanking the 13q11-12 breakpoint and spanning the 8p11 breakpoint have been isolated. These YACs will facilitate characterization of the genes involved in this rearrangement.

Original language	English
Pages (from-to)	70-73
Number of pages	4
Journal	Genes Chromosomes and Cancer
Volume	21
Issue number	1
DOIs	https://doi.org/10.1002/(SICI)1098-2264(199801)21:1<70::AID-GCC9>3.0.CO;2-5
Publication status	Published - 7 Dec 1998

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10.1002/(SICI)1098-2264(199801)21:1<70::AID-GCC9>3.0.CO;2-5

Cite this

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abstract = "Fourteen cases of an atypical myeloproliferative disorder associated with consistent translocations involving 8p11-12 have previously been described. A t(8;13)(p11;q11-12) was the most common, but variant t(8;9)(p11- 12;q32-34) and t(6;8)(q27;p12) were also reported. Here we have used a series of yeast artificial chromosomes (YACs) derived from the 8p11 and 13q11-12 regions to analyse one of the t(8;13) cases by fluorescence in situ hybridization (FISH). YACs flanking the 13q11-12 breakpoint and spanning the 8p11 breakpoint have been isolated. These YACs will facilitate characterization of the genes involved in this rearrangement.",

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AU - Smedley, Damian

AU - Somers, Gino

AU - Venter, Deon

AU - Chow, Chung Wo

AU - Cooper, Colin

AU - Shipley, Janet

PY - 1998/12/7

Y1 - 1998/12/7

N2 - Fourteen cases of an atypical myeloproliferative disorder associated with consistent translocations involving 8p11-12 have previously been described. A t(8;13)(p11;q11-12) was the most common, but variant t(8;9)(p11- 12;q32-34) and t(6;8)(q27;p12) were also reported. Here we have used a series of yeast artificial chromosomes (YACs) derived from the 8p11 and 13q11-12 regions to analyse one of the t(8;13) cases by fluorescence in situ hybridization (FISH). YACs flanking the 13q11-12 breakpoint and spanning the 8p11 breakpoint have been isolated. These YACs will facilitate characterization of the genes involved in this rearrangement.

AB - Fourteen cases of an atypical myeloproliferative disorder associated with consistent translocations involving 8p11-12 have previously been described. A t(8;13)(p11;q11-12) was the most common, but variant t(8;9)(p11- 12;q32-34) and t(6;8)(q27;p12) were also reported. Here we have used a series of yeast artificial chromosomes (YACs) derived from the 8p11 and 13q11-12 regions to analyse one of the t(8;13) cases by fluorescence in situ hybridization (FISH). YACs flanking the 13q11-12 breakpoint and spanning the 8p11 breakpoint have been isolated. These YACs will facilitate characterization of the genes involved in this rearrangement.

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Characterization of a t(8;13)(p11;q11-12) in an atypical myeloproliferative disorder

Abstract

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