Characterization of -Lactamase and Porin Mutants of Enterobacteriaceae Selected with Ceftaroline + Avibactam (NXL104).

David M Livermore, Shazad Mushtaq, Kevin Barker, Russell Hope, Marina Warner, Neil Woodford

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)

Abstract

Ceftaroline + avibactam (NXL104) is a novel inhibitor combination active against Enterobacteriaceae with class A and C β-lactamases. We investigated its risk of mutational resistance.
Original languageEnglish
Pages (from-to)1354-1358
Number of pages5
JournalJournal of Antimicrobial Chemotherapy
Volume67
Issue number6
DOIs
Publication statusPublished - Jun 2012

Keywords

  • Anti-Bacterial Agents
  • Azabicyclo Compounds
  • Cephalosporins
  • Drug Resistance, Bacterial
  • Enterobacteriaceae
  • Genomic Instability
  • Microbial Sensitivity Tests
  • Mutant Proteins
  • Phenotype
  • Porins
  • Selection, Genetic
  • beta-Lactamases

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