Characterization of two non-locus of enterocyte effacement-encoded type III-translocated effectors, NleC and NleD, in attaching and effacing pathogens

Olivier Marches, Siouxsie Wiles, Francis Dziva, Roberto M. La Ragione, Stephanie Schuller, Angus Best, Alan D. Phillips, Elizabeth L. Hartland, Martin J. Woodward, Mark P. Stevens, Gad Frankel

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Intestinal colonization by enteropathogenic and enterohemorrhagic Escherichia coli requires the locus of enterocyte effacement-encoded type III secretion system. We report that NleC and NleD are translocated into host cells via this system. Deletion mutants induced attaching and effacing lesions in vitro, while infection of calves or lambs showed that neither gene was required for colonization.
Original languageEnglish
Pages (from-to)8411-8417
Number of pages7
JournalInfection and Immunity
Issue number12
Publication statusPublished - Dec 2005

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