Chemical and chemoenzymatic syntheses of bacillithiol, a unique low molecular weight thiol amongst low G + C Gram positive bacteria

Sunil V. Sharma, Vishnu K. Jothivasan, Gerald L. Newton, Heather Upton, Judy I. Wakabayashi, Melissa G. Kane, Alexandra A. Roberts, Mamta Rawat, James J. La Clair, Chris J. Hamilton

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

The full monty: The recently discovered thiol cofactor bacillithiol (BSH), its biosynthetic precursors, and its symmetrical disulfide are prepared in two ways. The fosfomycin resistance protein (FosB) is shown to be a BSH-utilizing enzyme. It displays bacillithiol-S-transferase activity with a strong preference for BSH over L-cysteine as its thiol substrate.
Original languageEnglish
Pages (from-to)7101-7104
Number of pages4
JournalAngewandte Chemie International Edition
Volume50
Issue number31
DOIs
Publication statusPublished - 25 Jul 2011

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