Chemical diversity and biological activities of marine sponges of the genus Suberea: A systematic review

Amr El-Demerdash; Atanas G. Atanasov; Olaf K. Horbanczuk; Mohamed A. Tammam; Mamdouh Abdel-Mogib; John N. A. Hooper; Nazim Sekeroglu; Ali Al-Mourabit; Anake Kijjoa

doi:10.3390/md17020115

Chemical diversity and biological activities of marine sponges of the genus Suberea: A systematic review

Amr El-Demerdash, Atanas G. Atanasov, Olaf K. Horbanczuk, Mohamed A. Tammam, Mamdouh Abdel-Mogib, John N. A. Hooper, Nazim Sekeroglu, Ali Al-Mourabit, Anake Kijjoa

Research output: Contribution to journal › Review article › peer-review

39 Citations (Scopus)

Abstract

Marine natural products (MNPs) continue to be in the spotlight in the global drug discovery endeavor. Currently, more than 30,000 structurally diverse secondary metabolites from marine sources have been isolated, making MNPs a profound, renewable source to investigate novel drug compounds. Marine sponges of the genus Suberea (family: Aplysinellidae) are recognized as producers of bromotyrosine derivatives, which are considered distinct chemotaxonomic markers for the marine sponges belonging to the order Verongida. This class of compounds exhibits structural diversity, ranging from simple monomeric molecules to more complex molecular scaffolds, displaying a myriad of biological and pharmacological potentialities. In this review, a comprehensive literature survey covering the period of 1998-2018, focusing on the chemistry and biological/pharmacological activities of marine natural products from marine sponges of the genus Suberea, with special attention to the biogenesis of the different skeletons of halogenated compounds, is presented.

Original language	English
Article number	115
Journal	Marine Drugs
Volume	17
Issue number	2
DOIs	https://doi.org/10.3390/md17020115
Publication status	Published - 12 Feb 2019

Keywords

Bioactivities
Biosynthesis
Bromotyrosine derivatives
Marine sponges
Suberea
Verongida

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/md17020115Licence: CC BY

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title = "Chemical diversity and biological activities of marine sponges of the genus Suberea: A systematic review",

abstract = "Marine natural products (MNPs) continue to be in the spotlight in the global drug discovery endeavor. Currently, more than 30,000 structurally diverse secondary metabolites from marine sources have been isolated, making MNPs a profound, renewable source to investigate novel drug compounds. Marine sponges of the genus Suberea (family: Aplysinellidae) are recognized as producers of bromotyrosine derivatives, which are considered distinct chemotaxonomic markers for the marine sponges belonging to the order Verongida. This class of compounds exhibits structural diversity, ranging from simple monomeric molecules to more complex molecular scaffolds, displaying a myriad of biological and pharmacological potentialities. In this review, a comprehensive literature survey covering the period of 1998-2018, focusing on the chemistry and biological/pharmacological activities of marine natural products from marine sponges of the genus Suberea, with special attention to the biogenesis of the different skeletons of halogenated compounds, is presented.",

keywords = "Bioactivities, Biosynthesis, Bromotyrosine derivatives, Marine sponges, Suberea, Verongida",

author = "Amr El-Demerdash and Atanasov, {Atanas G.} and Horbanczuk, {Olaf K.} and Tammam, {Mohamed A.} and Mamdouh Abdel-Mogib and Hooper, {John N. A.} and Nazim Sekeroglu and Ali Al-Mourabit and Anake Kijjoa",

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doi = "10.3390/md17020115",

language = "English",

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Chemical diversity and biological activities of marine sponges of the genus Suberea: A systematic review. / El-Demerdash, Amr; Atanasov, Atanas G.; Horbanczuk, Olaf K.; Tammam, Mohamed A.; Abdel-Mogib, Mamdouh; Hooper, John N. A.; Sekeroglu, Nazim; Al-Mourabit, Ali; Kijjoa, Anake.

In: Marine Drugs, Vol. 17, No. 2, 115, 12.02.2019.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Chemical diversity and biological activities of marine sponges of the genus Suberea: A systematic review

AU - El-Demerdash, Amr

AU - Atanasov, Atanas G.

AU - Horbanczuk, Olaf K.

AU - Tammam, Mohamed A.

AU - Abdel-Mogib, Mamdouh

AU - Hooper, John N. A.

AU - Sekeroglu, Nazim

AU - Al-Mourabit, Ali

AU - Kijjoa, Anake

PY - 2019/2/12

Y1 - 2019/2/12

N2 - Marine natural products (MNPs) continue to be in the spotlight in the global drug discovery endeavor. Currently, more than 30,000 structurally diverse secondary metabolites from marine sources have been isolated, making MNPs a profound, renewable source to investigate novel drug compounds. Marine sponges of the genus Suberea (family: Aplysinellidae) are recognized as producers of bromotyrosine derivatives, which are considered distinct chemotaxonomic markers for the marine sponges belonging to the order Verongida. This class of compounds exhibits structural diversity, ranging from simple monomeric molecules to more complex molecular scaffolds, displaying a myriad of biological and pharmacological potentialities. In this review, a comprehensive literature survey covering the period of 1998-2018, focusing on the chemistry and biological/pharmacological activities of marine natural products from marine sponges of the genus Suberea, with special attention to the biogenesis of the different skeletons of halogenated compounds, is presented.

AB - Marine natural products (MNPs) continue to be in the spotlight in the global drug discovery endeavor. Currently, more than 30,000 structurally diverse secondary metabolites from marine sources have been isolated, making MNPs a profound, renewable source to investigate novel drug compounds. Marine sponges of the genus Suberea (family: Aplysinellidae) are recognized as producers of bromotyrosine derivatives, which are considered distinct chemotaxonomic markers for the marine sponges belonging to the order Verongida. This class of compounds exhibits structural diversity, ranging from simple monomeric molecules to more complex molecular scaffolds, displaying a myriad of biological and pharmacological potentialities. In this review, a comprehensive literature survey covering the period of 1998-2018, focusing on the chemistry and biological/pharmacological activities of marine natural products from marine sponges of the genus Suberea, with special attention to the biogenesis of the different skeletons of halogenated compounds, is presented.

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KW - Biosynthesis

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KW - Marine sponges

KW - Suberea

KW - Verongida

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DO - 10.3390/md17020115

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ER -

Chemical diversity and biological activities of marine sponges of the genus Suberea: A systematic review

Abstract

Keywords

UN SDGs

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