Chemoenzymatic synthesis of GM3, Lewis x and sialyl Lewis x oligosaccharides in 13C-enriched form

Mark A. Probert, Mark J. Milton, Richard Harris, Sergio Schenkman, Jonathan M. Brown, Steven W. Romans, Robert A. Field

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Abstract

In connection with studies on the solution and protein-bound conformation of oligosaccharides, wand had reason to consider the application of 13C-enriched sugars. Herein we describe the synthesis of ganglioside GM3 trisaccharide (1), Lewis x trisaccharide (2) and the sialyl Lewis x tetrasaccharide (3) from [U-13C]-D-Glc, [U-13C]- and [U-13C]-pyruvate.

Original languageEnglish
Pages (from-to)5861-5864
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number33
DOIs
Publication statusPublished - 18 Aug 1997

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