Chequerboard titration of cephalosporin CXA-101 (FR264205) and tazobactam versus beta-lactamase-producing Enterobacteriaceae

David M Livermore, Shazad Mushtaq, Yigong Ge

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The developmental oxyimino-cephalosporin CXA-101 (FR264205) is notable for having greater antipseudomonal activity than ceftazidime. It is active against Enterobacteriaceae too, but is compromised by extended-spectrum, AmpC and carbapenem-hydrolysing beta-lactamases. We investigated the tazobactam concentrations needed to potentiate this cephalosporin against strains with these mechanisms.
Original languageEnglish
Pages (from-to)1972-4
Number of pages3
JournalJournal of Antimicrobial Chemotherapy
Volume65
Issue number9
DOIs
Publication statusPublished - Sep 2010

Keywords

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Cephalosporins
  • Enterobacteriaceae
  • Enzyme Inhibitors
  • Microbial Sensitivity Tests
  • Penicillanic Acid
  • beta-Lactamases

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