Abstract
The developmental oxyimino-cephalosporin CXA-101 (FR264205) is notable for having greater antipseudomonal activity than ceftazidime. It is active against Enterobacteriaceae too, but is compromised by extended-spectrum, AmpC and carbapenem-hydrolysing beta-lactamases. We investigated the tazobactam concentrations needed to potentiate this cephalosporin against strains with these mechanisms.
Original language | English |
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Pages (from-to) | 1972-4 |
Number of pages | 3 |
Journal | Journal of Antimicrobial Chemotherapy |
Volume | 65 |
Issue number | 9 |
DOIs | |
Publication status | Published - Sep 2010 |
Keywords
- Anti-Bacterial Agents
- Bacterial Proteins
- Cephalosporins
- Enterobacteriaceae
- Enzyme Inhibitors
- Microbial Sensitivity Tests
- Penicillanic Acid
- beta-Lactamases