Chequerboard titration of cephalosporin CXA-101 (FR264205) and tazobactam versus beta-lactamase-producing Enterobacteriaceae

David M Livermore; Shazad Mushtaq; Yigong Ge

doi:10.1093/jac/dkq248

Chequerboard titration of cephalosporin CXA-101 (FR264205) and tazobactam versus beta-lactamase-producing Enterobacteriaceae

David M Livermore, Shazad Mushtaq, Yigong Ge

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

Abstract

The developmental oxyimino-cephalosporin CXA-101 (FR264205) is notable for having greater antipseudomonal activity than ceftazidime. It is active against Enterobacteriaceae too, but is compromised by extended-spectrum, AmpC and carbapenem-hydrolysing beta-lactamases. We investigated the tazobactam concentrations needed to potentiate this cephalosporin against strains with these mechanisms.

Original language	English
Pages (from-to)	1972-4
Number of pages	3
Journal	Journal of Antimicrobial Chemotherapy
Volume	65
Issue number	9
DOIs	https://doi.org/10.1093/jac/dkq248
Publication status	Published - Sept 2010

Keywords

Anti-Bacterial Agents
Bacterial Proteins
Cephalosporins
Enterobacteriaceae
Enzyme Inhibitors
Microbial Sensitivity Tests
Penicillanic Acid
beta-Lactamases

Access to Document

10.1093/jac/dkq248

Cite this

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title = "Chequerboard titration of cephalosporin CXA-101 (FR264205) and tazobactam versus beta-lactamase-producing Enterobacteriaceae",

abstract = "The developmental oxyimino-cephalosporin CXA-101 (FR264205) is notable for having greater antipseudomonal activity than ceftazidime. It is active against Enterobacteriaceae too, but is compromised by extended-spectrum, AmpC and carbapenem-hydrolysing beta-lactamases. We investigated the tazobactam concentrations needed to potentiate this cephalosporin against strains with these mechanisms.",

keywords = "Anti-Bacterial Agents, Bacterial Proteins, Cephalosporins, Enterobacteriaceae, Enzyme Inhibitors, Microbial Sensitivity Tests, Penicillanic Acid, beta-Lactamases",

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KW - Anti-Bacterial Agents

KW - Bacterial Proteins

KW - Cephalosporins

KW - Enterobacteriaceae

KW - Enzyme Inhibitors

KW - Microbial Sensitivity Tests

KW - Penicillanic Acid

KW - beta-Lactamases

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