Chitin butyrate coated electrospun nylon-6 fibers for biomedical applications

Hem Raj Pant, Han Joo Kim, Lok Ranjan Bhatt, Mahesh Kumar Joshi, Eun Kyo Kim, Jeong In Kim, Abdalla Abdal-Hay, K. S. Hui, Cheol Sang Kim

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33 Citations (Scopus)

Abstract

In this study, we describe the preparation and characterizations of chitin butyrate (CB) coated nylon-6 nanofibers using single-spinneret electrospinning of blends solution. The physicochemical properties of nylon-6 composite fibers with different proportions of CB to nylon-6 were determined using FE-SEM, TEM, FT-IR spectroscopy, and water contact angle measurement. FE-SEM and TEM images revealed that the nylon-6 and CB were immiscible in the as-spun nanofibers, and phase separated nanofiber morphology becomes more pronounced with increasing amounts of CB. The bone formation ability of composite fibers was evaluated by incubating in biomimetic simulated body fluid. In order to assay the cytocompatibility and cell behavior on the composite scaffolds, osteoblast cells were seeded on the matrix. Results suggest that the deposition of CB layer on the surface of nylon-6 could increase its cell compatibility and bone formation ability. Therefore, as-synthesized nanocomposite fibrous mat has great potentiality in hard tissue engineering.

Original languageEnglish
Pages (from-to)538-544
Number of pages7
JournalApplied Surface Science
Volume285
Issue numberPart B
Early online date26 Aug 2013
DOIs
Publication statusPublished - 15 Nov 2013

Keywords

  • Biomaterials
  • Chitin butyrate
  • Electrospinning
  • Nanofibers
  • Nylon-6

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