Abstract

Objective

To explore the relative frequency of a family history of cholesteatoma in patients with known cholesteatoma, and whether bilateral disease or earlier diagnosis is more likely in those with a family history. Associations between cleft lip or palate and bilateral disease and age of diagnosis were also explored.

Design
An online survey of patients with diagnosed cholesteatoma was conducted between October 2017 and April 2019.

Participants
The sample consisted of patients recruited from two UK clinics and self‐selected respondents recruited internationally via social media.

Main outcome measures
Side of cholesteatoma, whether respondents had any family history of cholesteatoma, age of diagnosis and personal or family history of cleft lip or palate were recorded.

Results
Of 857 respondents, 89 (10.4%) reported a positive family history of cholesteatoma. Respondents with a family history of cholesteatoma were more likely to have bilateral cholesteatoma (P = .001, odds ratio (OR) 2.15, 95% confidence interval (CI) 1.35‐3.43), but there was no difference in the age of diagnosis (P = .23). Those with a history of cleft lip or palate were not more likely to have bilateral disease (P = .051, OR 2.71, CI 1.00‐7.38), and there was no difference in age of diagnosis (P = .11).

Conclusion
The relatively high proportion of respondents that reported a family history of cholesteatoma offers supporting evidence of heritability in cholesteatoma. The use of social media to recruit respondents to this survey means that the results cannot be generalised to other populations with cholesteatoma. Further population‐based research is suggested to determine the heritability of cholesteatoma.
Original languageEnglish
Pages (from-to)500-505
Number of pages6
JournalClinical Otolaryngology
Volume45
Issue number4
Early online date9 Apr 2020
DOIs
Publication statusPublished - Jul 2020

Keywords

  • bilateral
  • cholesteatoma
  • cleft lip
  • cleft palate
  • family history
  • genetic

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